Influence of donor-recipient sex mismatch on long-term survival of pancreatic grafts

被引:12
|
作者
Li, Zhiwei [1 ]
Mei, Shengmin [1 ]
Xiang, Jie [1 ]
Zhou, Jie [1 ]
Zhang, Qijun [1 ]
Yan, Sheng [1 ,2 ]
Zhou, Lin [1 ,2 ]
Hu, Zhenhua [1 ,2 ]
Zheng, Shusen [1 ,2 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 1,Minist Publ Hlth, Sch Med,Key Lab Combined Multiorgan Transplantat, Dept Surg,Div Hepatobiliary & Pancreat Surg,Key L, Hangzhou 310003, Zhejiang, Peoples R China
[2] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
基金
中国国家自然科学基金;
关键词
LIVER-TRANSPLANTATION; KIDNEY-TRANSPLANTATION; RISK-FACTOR; H-Y; FEMALE GENDER; OUTCOMES; AGE; INFECTION; REJECTION; QUALITY;
D O I
10.1038/srep29298
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To assess the role of sex mismatch on graft survival after pancreas transplantation. We evaluated 24,195 pancreas-transplant recipients reported in the Scientific Registry of Transplant Recipients over a 25-year period. Pancreatic graft survival (PGS) was analyzed according to donor-recipient sex pairing using Kaplan-Meier estimations. Hazard ratios were estimated using Cox proportional hazard models. A total of 14,187 male and 10,008 female recipients were included in final analyses. Mean follow-up was 8.3 +/- 5.7 years. In multivariate analyses, neither recipient sex nor donor sex was associated with pancreatic graft failure (PGF), but donor-recipient sex mismatch (regardless of recipient sex) was an independent predictor of PGS (HR, 1.09; 95% CI, 1.04-1.14; p < 0.001). Compared with M -> M sex-matched recipients in univariate analyses, M -> F and F -> M sex mismatches were associated with an increased risk of PGF. Adjustment for significant recipient and donor factors eliminated the association between F -> M sex mismatch and PGF (HR, 1.02; 95% CI, 0.93-1.10; p = 0.752), but not M -> F (1.09; 1.02-1.17; 0.020). Stratified analyses suggested that the negative effect of donor-recipient sex mismatch could be neutralized in older patients. These findings suggest that donor-recipient sex pairing should be taken into consideration in organ-allocation strategies.
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页数:8
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