Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women

被引:314
作者
Farnsworth, E
Luscombe, ND
Noakes, M
Wittert, G
Argyiou, E
Clifton, PM
机构
[1] CSIRO, Hlth Sci & Nutr, Adelaide, SA 5000, Australia
[2] Univ Adelaide, Dept Physiol, Adelaide, SA 5000, Australia
[3] Univ Adelaide, Dept Med, Adelaide, SA 5000, Australia
[4] Univ Sheffield, Ctr Human Nutr, Sheffield, S Yorkshire, England
关键词
weight loss; protein; body composition; glycemic response; lipids; humans;
D O I
10.1093/ajcn/78.1.31
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: It is not clear whether varying the protein-to-carbohydrate ratio of weight-loss diets benefits body composition or metabolism. Objective: The objective was to compare the effects of 2 weight-loss diets differing in protein-to-carbohydrate ratio on body composition, glucose and lipid metabolism, and markers of bone turnover. Design: A parallel design included either a high-protein diet of meat, poultry, and dairy foods (HP diet: 27% of energy as protein, 44% as carbohydrate, and 29% as fat) or a standard-protein diet low in those foods (SP diet: 16% of energy as protein, 57% as carbohydrate, and 27% as fat) during 12 wk of energy restriction (6-6.3 MJ/d) and 4 wk of energy balance (approximate to8.2 MJ/d). Fifty-seven overweight volunteers with fasting insulin concentrations > 12 mU/L completed the study. Results: Weight loss (7.9 +/- 0.5 kg) and total fat loss (6.9 +/- 0.4 kg) did not differ between diet groups. In women, total lean mass was significantly (P = 0.02) better preserved with the HP diet (-0.1 +/- 0.3 kg) than with the SP diet (-1.5 +/- 0.3 kg). Those fed the HP diet had significantly (P < 0.03) less glycemic response at weeks 0 and 16 than did those fed the SP diet. After weight loss, the glycemic response decreased significantly (P < 0.05) more in the HP diet group. The reduction in serum triacylglycerol concentrations was significantly (P < 0.05) greater in the HP diet group (23%) than in the SP diet group (10%). Markers of bone turnover, calcium excretion, and systolic blood pressure were unchanged. Conclusion: Replacing carbohydrate with protein from meat, poultry, and dairy foods has beneficial metabolic effects and no adverse effects on markers of bone turnover or calcium excretion.
引用
收藏
页码:31 / 39
页数:9
相关论文
共 50 条
[41]   HDL-sphingomyelin reduction after weight loss by an energy-restricted diet is associated with the improvement of lipid profile, blood pressure, and decrease of insulin resistance in overweight/obese patients [J].
Martinez-Ramirez, Miriam ;
Madero, Magdalena ;
Vargas-Alarcon, Gilberto ;
Vargas-Barron, Jesus ;
Manuel Fragoso, Jose ;
Manuel Rodriguez-Perez, Jose ;
Martinez-Sanchez, Carlos ;
Gonzalez-Pacheco, Hector ;
Bautista-Perez, Rocio ;
Carreon-Torres, Elizabeth ;
Perez-Mendez, Oscar .
CLINICA CHIMICA ACTA, 2016, 454 :77-81
[42]   Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men [J].
Desroches, S ;
Chouinard, PY ;
Galibois, I ;
Corneau, L ;
Delisle, J ;
Lamarche, B ;
Couture, P ;
Bergeron, N .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 82 (02) :309-319
[43]   Effect of aerobic and resistance exercises on body composition and quality of life in overweight and obese women: a randomized control trial [J].
Cicek, Guner ;
Ozdurak Singin, Rabia Hurrem .
UNIVERSA MEDICINA, 2023, 42 (01) :70-83
[44]   The Effect of Birth Weight on Low-Energy Diet-Induced Changes in Body Composition and Substrate-Energy Metabolism in Obese Women [J].
Ortega, Francisco B. ;
Ruiz, Jonatan R. ;
Pilar Alkorta, Maria ;
Larrarte, Eider ;
Simon, Edurne ;
Ares, Raquel ;
Labayen, Idoia .
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2011, 30 (02) :134-140
[45]   One-month of a low-energy diet, with no additional effect of high-protein, reduces Obstructive Sleep Apnea severity and improve metabolic parameters in obese males [J].
de Melo, Camila Maria ;
Quaresma, Marcus Vinicius Lucio dos Santos ;
del Re, Mariana Pantalea ;
Ribeiro, Sandra Maria Lima ;
Antunes, Hanna Karen Moreira ;
Togeiro, Sonia M. ;
Tufik, Sergio ;
de Mello, Marco Tulio .
CLINICAL NUTRITION ESPEN, 2021, 42 :82-89
[46]   Incorporating Milk Protein Isolate into an Energy-Restricted Western-Style Eating Pattern Augments Improvements in Blood Pressure and Triglycerides, but Not Body Composition Changes in Adults Classified as Overweight or Obese: A Randomized Controlled Trial [J].
Hudson, Joshua L. ;
Zhou, Jing ;
Kim, Jung Eun ;
Campbell, Wayne W. .
NUTRIENTS, 2020, 12 (03)
[47]   Effects of a high-protein, low-glycemic-index diet on body weight and waist circumference in late postmenopausal women: a randomized controlled trial [J].
Silva, Thais Rasia ;
Lago, Suzana Cardona ;
Fighera, Tayane Muniz ;
Spritzer, Poli Mara .
ARCHIVES OF ENDOCRINOLOGY METABOLISM, 2024, 68
[48]   Comparison of the effect of daily consumption of probiotic compared with low-fat conventional yogurt on weight loss in healthy obese women following an energy-restricted diet: a randomized controlled trial [J].
Madjd, Ameneh ;
Taylor, Moira A. ;
Mousavi, Neda ;
Delavari, Alireza ;
Malekzadeh, Reza ;
Macdonald, Ian A. ;
Farshchi, Hamid R. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2016, 103 (02) :323-329
[49]   Interactive effects of an isocaloric high-protein diet and resistance exercise on body composition, ghrelin, and metabolic and hormonal parameters in untrained young men: A randomized clinical trial [J].
Kim, Hyun Ho ;
Kim, Yun Jin ;
Lee, Sang Yeoup ;
Jeong, Dong Wook ;
Lee, Jeong Gyu ;
Yi, Yu Hyone ;
Cho, Young Hye ;
Choi, Eun Jung ;
Kim, Hyun Jun .
JOURNAL OF DIABETES INVESTIGATION, 2014, 5 (02) :242-247
[50]   Effect of an Energy-Restricted, Nutritionally Complete, Higher Protein Meal Plan on Body Composition and Mobility in Older Adults With Obesity: A Randomized Controlled Trial [J].
Beavers, Kristen M. ;
Nesbit, Beverly A. ;
Kiel, Jessica R. ;
Sheedy, Jessica L. ;
Arterburn, Linda M. ;
Collins, Amy E. ;
Ford, Sherri A. ;
Henderson, Rebecca M. ;
Coleman, Christopher D. ;
Beavers, Daniel P. .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2019, 74 (06) :929-935