Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT)

被引:51
作者
Hutchinson, J. Ciaran [1 ,2 ]
Shelmerdine, Susan C. [2 ,3 ]
Simcock, Ian C. [2 ,3 ]
Sebire, Neil J. [1 ,2 ]
Arthurs, Owen J. [2 ,3 ]
机构
[1] Hosp Children NHS Fdn Trust, Dept Histopathol, Great Ormond St, London, England
[2] UCL, Inst Child Hlth, Great Ormond St, London, England
[3] Hosp Children NHS Fdn Trust, Dept Radiol, Great Ormond St, London, England
关键词
POSTMORTEM MICROCOMPUTED TOMOGRAPHY; HIGH-RESOLUTION; DEVELOPMENTAL BIOLOGY; BRAIN; FEATURES; TUMORS; TOOL;
D O I
10.1259/bjr.20170113
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Microfocus CT (micro-CT) has traditionally been used in industry and preclinical studies, although it may find new applicability in the routine clinical setting. It can provide high-resolution three-dimensional digital imaging data sets to the same level of detail as microscopic examination without the need for tissue dissection. Micro-CT is already enabling non-invasive detailed internal assessment of various tissue specimens, particularly in breast imaging and early gestational fetal autopsy, not previously possible from more conventional modalities such as MRI or CT. In this review, we discuss the technical aspects behind micro-CT image acquisition, how early work with small animal studies have informed our knowledge of human disease and the imaging performed so far on human tissue specimens. We conclude with potential future clinical applications of this novel and emerging technique.
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页数:10
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