LAMP-generated H+ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA

被引：22
作者：
Hua, Xiaoyu [1 ]
Yang, Enfen [1 ]
Yang, Wenting [1 ]
Yuan, Ruo [1 ]
Xu, Wenju [1 ]
机构：
[1] Southwest Univ, Key Lab Luminescent & Real Time Analyt Chem, Minist Educ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 83期
关键词：
MEDIATED ISOTHERMAL AMPLIFICATION; PH; PROBE;
D O I：
10.1039/c9cc06738h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, an ultrasensitive electrochemical biosensor is proposed for the quantification of the Flu A virus biomarker DNA (fDNA), and is based on loop-mediated isothermal amplification-generated hydrogen ions (LAMP-H+) which induce the formation of the dimer i-motif structure (DiMS) for signal transduction, coupled with exonuclease III (ExoIII)-assisted DNA walking for signal dual-amplification.
引用
收藏
页码：12463 / 12466
页数：4
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