Triggering of ovulation by a gonadotropin-releasing hormone (GnRH) agonist in patients pretreated with a GnRH antagonist

Objective: To determine if GnRH-agonist (GnRH-a) could induce a LH surge in patients where a GnRH antagonist was used to prevent premature spontaneous LH surge. Design: Pilot study. Patients: Five patients treated with ovarian stimulation and IUI for idiopathic infertility. Main Outcome Measures: Luteinizing hormone, FSH, and P plasma levels. Results: A LH and FSH surge as well as a P rise were obtained in the five patients studied. Conclusion: A GnRH-a successfully can induce an LH surge after GnRH antagonist administration. The effect of the antagonist on the quality of the GnRH-a-induced LH surge as well as the oocyte quality remain to be evaluated.