Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus

被引:98
作者
Wagner, Carol L. [1 ]
Taylor, Sarah N. [1 ]
Dawodu, Adekunle [2 ]
Johnson, Donna D. [3 ]
Hollis, Bruce W. [1 ]
机构
[1] Med Univ S Carolina, Dept Pediat, Div Neonatol, Charleston, SC 29425 USA
[2] Cincinnati Childrens Hosp Med Ctr, Global Hlth Ctr, Cincinnati, OH 45229 USA
[3] Med Univ S Carolina, Dept Obstet & Gynecol, Div Maternal Fetal Med, Charleston, SC 29425 USA
关键词
vitamin D; cholecalciferol; calcitriol; pregnancy; neonate; PARATHYROID-HORMONE CONCENTRATIONS; D DEFICIENCY; BREAST-CANCER; PLASMA; 25-HYDROXYVITAMIN-D; D SUPPLEMENTATION; HYPOVITAMINOSIS-D; HIGH PREVALENCE; D INSUFFICIENCY; MULTIPLE-SCLEROSIS; METABOLIC SYNDROME;
D O I
10.3390/nu4030208
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Despite its discovery a hundred years ago, vitamin D has emerged as one of the most controversial nutrients and prohormones of the 21st century. Its role in calcium metabolism and bone health is undisputed but its role in immune function and long-term health is debated. There are clear indicators from in vitro and animal in vivo studies that point to vitamin D's indisputable role in both innate and adaptive immunity; however, the translation of these findings to clinical practice, including the care of the pregnant woman, has not occurred. Until recently, there has been a paucity of data from randomized controlled trials to establish clear cut beneficial effects of vitamin D supplementation during pregnancy. An overview of vitamin metabolism, states of deficiency, and the results of recent clinical trials conducted in the U. S. are presented with an emphasis on what is known and what questions remain to be answered.
引用
收藏
页码:208 / 230
页数:23
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