Surface-engineered nanoporous gold nanoparticles for light-triggered drug release

被引：14

作者：

Kang, Tae Yeon ^{[1
]}

Park, Kyeongsoon ^{[2
]}

Kwon, Seung Hae ^{[3
]}

Chae, Weon-Sik ^{[4
]}

机构：

[1] Korea Basic Sci Inst, Gangneung Ctr, Kangnung 25457, South Korea

[2] Chung Ang Univ, Dept Syst Biotechnol, Anseong 17546, South Korea

[3] Korea Basic Sci Inst, Seoul Ctr, Seoul 02855, South Korea

[4] Korea Basic Sci Inst, Daegu Ctr, Daegu 41566, South Korea

来源：

OPTICAL MATERIALS | 2020年 / 106卷

关键词：

Plasmonic metal; Nanoporous gold; Drug release; Doxorubicin; AAO; DOXORUBICIN; DAUNORUBICIN; FABRICATION; THIOL;

D O I：

10.1016/j.optmat.2020.109985

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We studied light-triggered drug releasing performance using surface-engineered nanoporous gold nanoparticles (np-Au NPs). The np-Au NPs were prepared by applying templated pulsed electrochemical deposition for repeated Ag-AgAu nano-segments and subsequent selective Ag phase etching. The resulting np-Au NPs showed characteristic internal porous structure with a gap size of similar to 15 nm. The surface of the np-Au NPs was rationally modified with mercaptosuccinic acid (MSA) and mercaptopropionic acid (MPA) to control chemical binding force at interface. The MSA modified np-Au NPs showed the best light-triggered drug releasing performance for doxorubicin compared to those of the MPA modified np-Au and the bare np-Au NPs. From in vivo fluorescence imaging study, we found that the MSA modified np-Au NPs efficiently worked for controlled release of doxorubicin with light initiation in a mouse.

引用

页数：5

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