The therapeutic potential of curcumin: A review of clinical trials

被引：379

作者：

Salehi, Bahare ^{[1
]}

Stojanovic-Radic, Zorica ^{[2
]}

Matejic, Jelena ^{[3
]}

Sharifi-Rad, Mehdi ^{[4
]}

Kumar, Nanjangud V. Anil ^{[5
]}

Martins, Natalia ^{[6
,7
]}

Sharifi-Rad, Javad ^{[8
,9
]}

机构：

[1] Bam Univ Med Sci, Bam, Iran

[2] Univ Nis, Fac Sci & Math, Dept Biol & Ecol, Visegradska 33, Nish 18000, Serbia

[3] Univ Nis, Fac Med, Dept Pharm, Blvd Dr Zorana Dinatica 81, Nish 18000, Serbia

[4] Zabol Univ Med Sci, Dept Med Parasitol, Zabol 61663335, Iran

[5] Manipal Acad Higher Educ, Manipal Inst Technol, Dept Chem, Manipal 576104, Karnataka, India

[6] Univ Porto, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[7] Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal

[8] Zabol Univ Med Sci, Zabol Med Plants Res Ctr, Zabol, Iran

[9] Univ Winnipeg, Dept Chem, Richardson Coll Environm Sci Complex, Winnipeg, MB R3B 2G3, Canada

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 163卷

关键词：

Curcuma longa L; Secondary metabolites; Curcuminoids; Pharmacological effects; Clinical trials; RANDOMIZED CONTROLLED-TRIAL; MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND; METABOLIC SYNDROME; ORAL CURCUMIN; KNEE OSTEOARTHRITIS; OXIDATIVE STRESS; PHASE-I; BIOAVAILABLE CURCUMIN; PIPERINE COMBINATION;

D O I：

10.1016/j.ejmech.2018.12.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases. (C) 2018 Elsevier Masson SAS. All rights reserved.

引用

页码：527 / 545

页数：19