The effects of child abuse and neglect on cognitive functioning in adulthood

被引：257

作者：

Gould, Felicia ^{[1
]}

Clarke, Jennifer ^{[1
,2
]}

Heim, Christine ^{[3
]}

Harvey, Philip D. ^{[1
]}

Majer, Matthias ^{[3
]}

Nemeroff, Charles B. ^{[1
]}

机构：

[1] Univ Miami, Leonard M Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

[2] Univ Miami, Leonard M Miller Sch Med, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA

[3] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2012年 / 46卷 / 04期

关键词：

ELS; Cognition; Child abuse; POSTTRAUMATIC-STRESS-DISORDER; ANXIETY DISORDERS; MAJOR DEPRESSION; PTSD; IMPAIRMENT; MEMORY; TRAUMA; BRAIN; MOOD; NEUROBIOLOGY;

D O I：

10.1016/j.jpsychires.2012.01.005

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Aims: Recent research has revealed that early life trauma (ELS), including abuse (sexual and/or physical) and neglect, produce lasting changes in the CNS. We posited that cognitive deficits, often observed in psychiatric patients, result, in part, due to the neurobiological consequences of ELS. Additionally, we hypothesized that the nature and magnitude of cognitive deficits would differ according to the subtype of ELS experienced. Method: The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess neurocognitive functioning in 93 subjects (60 with ELS and 33 without). In the patients with a history of ELS, 35% and 16.7%, respectively, met criteria for current major depression and PTSD. Results: Significant associations between ELS status and CANTAB measures of memory and executive and emotional functioning were found. Conclusions: These data suggest that exposure to ELS results in a cascade of neurobiological changes associated with cognitive deficits in adulthood that vary according to the type of trauma experienced. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：500 / 506

页数：7

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