Synthesis of Malononitrile-Substituted Diarylmethines via 1,6-Addition of Masked Acyl Cyanides to para-Quinone Methides

被引：22

作者：

Zhao, Kun ^{[1
]}

Zhi, Ying ^{[1
]}

Wang, Ai ^{[2
]}

Enders, Dieter ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Inst Inorgan Chem, Landoltweg 1, D-52074 Aachen, Germany

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 04期

关键词：

diarylmethines; 1,6-addition; masked acyl cyanides; para-quinone methides; malononitrile-substituted diarylmethines; ASYMMETRIC 1,6-CONJUGATE ADDITION; EXPEDIENT ACCESS; BOND FORMATION; ACID; ESTERS; ALDEHYDES; ADDITION/AROMATIZATION; CONSTRUCTION; DERIVATIVES; CARBANIONS;

D O I：

10.1055/s-0036-1590947

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of malononitrile-substituted diarylmethines through 1,6-conjugate addition of paraquinone methides with masked acyl cyanide (MAC) reagents has been developed. Under mild conditions, the scalable reaction occurs in good to excellent yields providing a straightforward access to a series of malononitrile-substituted diarylmethines. The synthetic utility of this protocol has been demonstrated in the synthesis of bioactive compounds.

引用

页码：872 / 880

页数：9

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