Monitoring of Artemisinin, Dihydroartemisinin, and Artemether in Environmental Matrices Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

被引：25

作者：

Jessing, Karina Knudsmark ^{[1
]}

Juhler, Rene K. ^{[2
]}

Strobel, Bjarne Westergaard ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Basic Sci & Environm, DK-1871 Frederiksberg C, Denmark

[2] Geol Survey Denmark & Greenland GEUS, Dept Geochem, DK-1350 Copenhagen, Denmark

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 21期

关键词：

Artemisia annua; African soils; environment; antimalarial; natural contaminants; biomedicine; qinghaosu; Plasmodium falciparum; QINGHAOSU; ANNUA; ARTESUNATE; PLASMA; DRUG;

D O I：

10.1021/jf2027632

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The area cultivated with Artemisia annua for the extraction of the antimalarial compound artemisinin is increasing, but the environmental impact of this cultivation has not yet been studied A sensitive and robust method, using liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed for the determination of artemisinin in soil Dihydroartemisinin and artemether Were included in the method, and performance on analytical columns of both traditional C(18) phenyl-hexyl and porous shell particles-based Kinetex types was characterized The versatility of the method was demonstrated on surface water and groundwater samples and plant extracts The limit of detection was 55, 30 (25 ng/g soil), and 4 ng/mL for dihydroartemisinin, artemisinin, and artemether, respectively Method performance was demonstrated using naturally contaminated soil samples from A. annua fields in Kenya The highest observed concentrations were above EC(10) for lettuce growth Monitoring of artemisinin in soil with A annua crop production seems necessary to further understand the impact in the environment

引用

页码：11735 / 11743

页数：9

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