The interaction of ubiquinone-3 with phospholipid membranes

被引：5

作者：

Asai, Y ^{[1
]}

Watanabe, S

机构：

[1] Eisai & Co Ltd, Formulat Res Lab Kawashima, Kawashima, Gifu 5016195, Japan

[2] Eisai & Co Ltd, Tsukuba Res Labs, Ibaraki, Osaka 3002635, Japan

来源：

FEBS LETTERS | 1999年 / 446卷 / 01期

关键词：

ubiquinone-3; dipalmitoylphosphalidylcholine; monolayer-bilayer equilibrium; solubility; membrane fluidity;

D O I：

10.1016/S0014-5793(99)00203-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of ubiquinone-3 (UQ) on dipalmitoylphosphatidylcholine (DPPC) membrane were studied by surface monolayer, differential scanning calorimetry (DSC) and fluorescence techniques. DPPC and UQ are proved to be freely miscible in the mixed monolayer at an air/water interface, and to be partially miscible in bulk phase, i.e. bilayer and solid phase. There is a condensing interaction between UQ and DPPC in the UQ/DPPC mixed monolayers, The solubility of UQ in the DPPC is about 20 mole% and the solubility of DPPC in UQ is about 10 mole%, The membrane fluidity of DPPC was increased by the addition of UQ and the phase transition temperature was decreased. (C) 1999 Federation of European Biochemical Societies.

引用

页码：169 / 172

页数：4

共 18 条

[1] ON THE INTERACTION OF UBIQUINONES WITH PHOSPHOLIPID-BILAYERS [J].

ALONSO, A ;

GOMEZFERNANDEZ, JC ;

ARANDA, FJ ;

BELDA, FJF ;

GONI, FM .

FEBS LETTERS, 1981, 132 (01) :19-22

[2] MODIFICATION BY DIACYLGLYCEROL OF THE STRUCTURE AND INTERACTION OF VARIOUS PHOSPHOLIPID-BILAYER MEMBRANES [J].

DAS, S ;

RAND, RP .

BIOCHEMISTRY, 1986, 25 (10) :2882-2889

[3] LATERAL DIFFUSION IN HYDROPHOBIC REGION OF MEMBRANES - USE OF PYRENE EXCIMERS AS OPTICAL PROBES [J].

GALLA, HJ ;

SACKMANN, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 339 (01) :103-115

[4] PHOSPHOLIPID MONOLAYERS AT THE TRIOLEIN SALINE INTERFACE - PRODUCTION OF MICROEMULSION PARTICLES AND CONVERSION OF MONOLAYERS TO BILAYERS [J].

HANDA, T ;

SAITO, H ;

MIYAJIMA, K .

BIOCHEMISTRY, 1990, 29 (11) :2884-2890

[5]

HANDA T, 1985, PROG COLL POL SCI S, V71, P26

[6] FORMATION AND STRUCTURE OF STABLY DISPERSED SMALL PARTICLES COMPOSED OF PHOSPHATIDYLCHOLINE AND UBIQUINONE-10 - COEXISTENCE OF EMULSION PARTICLES WITH BILAYER VESICLES [J].

HANDA, T ;

ASAI, Y ;

MIYAJIMA, K ;

KAWASHIMA, Y ;

KAYANO, M ;

IDA, K ;

IKEUCHI, T .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1991, 143 (01) :205-213

[7] INTERACTIONS AND STRUCTURE-ORGANIZATIONS OF MENAQUINONE-4 AND EGG-YOLK PHOSPHATIDYLCHOLINE MIXTURES - FORMATION OF BILAYER AND NONBILAYER STRUCTURES IN AN AQUEOUS-MEDIUM [J].

HANDA, T ;

ASAI, Y ;

KOMATSU, H ;

MIYAJIMA, K .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1992, 153 (02) :303-313

[8] FLUORESCENCE PROBE STUDIES OF THE DISTRIBUTION OF UBIQUINONE HOMOLOGS IN BILAYERS OF DIPALMITOYLGLYCEROPHOSPHOCHOLINE [J].

KATSIKAS, H ;

QUINN, PJ .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 131 (03) :607-612

[9] FURTHER EVIDENCE FOR POOL FUNCTION OF UBIQUINONE AS DERIVED FROM INHIBITION OF ELECTRON-TRANSPORT BY ANTIMYCIN [J].

KROGER, A ;

KLINGENBERG, M .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1973, 39 (02) :313-323

[10]

KROGER A, 1974, BIOCHIM BIOPHYS ACTA, V13, P103

← 1 2 →