Acupuncture Alleviates the Affective Dimension of Pain in a Rat Model of Inflammatory Hyperalgesia

被引：20
作者：
Zhang, Yu [1 ,2 ]
Meng, Xianze [1 ,3 ]
Li, Aihui [1 ]
Xin, Jiajia [1 ]
Berman, Brian M. [1 ]
Lao, Lixing [1 ]
Tan, Ming [4 ]
Ren, Ke [5 ]
Zhang, Rui-Xin [1 ]
机构：
[1] Univ Maryland, Ctr Integrat Med, Sch Med, Baltimore, MD 21201 USA
[2] Shanxi Med Univ, Dept Neurobiol, Taiyuan 030001, Shanxi, Peoples R China
[3] Second Mil Med Univ, Dept Tradit Chinese Med, Shanghai Changzheng Hosp, Shanghai 200001, Peoples R China
[4] Univ Maryland, Greenebaum Canc Ctr, Div Biostat, Baltimore, MD 21201 USA
[5] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA
来源：
NEUROCHEMICAL RESEARCH | 2011年 / 36卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Acupuncture; Opioid; Anterior cingulate cortex; Pain; Complete Freund's adjuvant; ANTERIOR CINGULATE CORTEX; ESCAPE/AVOIDANCE BEHAVIOR; DESCENDING CONTROL; NMDA RECEPTORS; NEUROPEPTIDE-Y; EXPRESSION; ELECTROACUPUNCTURE; ANXIETY; MECHANISMS; ANALGESIA;
D O I：
10.1007/s11064-011-0534-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although studies demonstrate that electroacupuncture (EA) alleviates the sensory dimension of pain, they have not addressed EA's effect on the affective dimension. An inflammatory pain rat model, produced by a complete Freund adjuvant (CFA) injection into the hind paw, was combined with a conditioned place avoidance test to determine EA's effects and its underpinning mechanism on the affective dimension of pain. CFA-injected rats showed place aversion, i.e. the affective dimension of pain, by spending less time in a pain-paired compartment after conditioning than before, while saline-injected rats did not. CFA rats given EA treatment at GB30 before a post-conditioning test showed no aversion to the pain-paired compartment, indicating that EA inhibited the affective response. Intra-rostral anterior cingulate cortex (rACC) administration of a kappa-, but not mu-opioid receptor antagonist, blocked EA action. These data demonstrate that EA activates opioid receptors in the rACC to inhibit the affective dimension of pain.
引用
收藏
页码：2104 / 2110
页数：7
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