Microvascular responsiveness in obesity: implications for therapeutic intervention

被引:49
作者
Bagi, Zsolt [1 ,2 ]
Feher, Attila [2 ]
Cassuto, James [2 ]
机构
[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
[2] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA
关键词
obesity; microcirculation; coronary flow; nitric oxide; hydrogen peroxide; adipocyte; statin; angiotensin converting enzyme inhibitors; thiazolidinedione; antioxidants; NITRIC-OXIDE SYNTHASE; ANGIOTENSIN-CONVERTING ENZYME; CORONARY BLOOD-FLOW; ENDOTHELIUM-DEPENDENT RELAXATION; IMPROVES INSULIN SENSITIVITY; CA2+-ACTIVATED K+ CHANNELS; SMOOTH-MUSCLE-CELLS; HYDROGEN-PEROXIDE; ADIPOSE-TISSUE; OXIDATIVE STRESS;
D O I
10.1111/j.1476-5381.2011.01606.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Obesity has detrimental effects on the microcirculation. Functional changes in microvascular responsiveness may increase the risk of developing cardiovascular complications in obese patients. Emerging evidence indicates that selective therapeutic targeting of the microvessels may prevent life-threatening obesity-related vascular complications, such as ischaemic heart disease, heart failure and hypertension. It is also plausible that alterations in adipose tissue microcirculation contribute to the development of obesity. Therefore, targeting adipose tissue arterioles could represent a novel approach to reducing obesity. This review aims to examine recent studies that have been focused on vasomotor dysfunction of resistance arteries in obese humans and animal models of obesity. Particularly, findings in coronary resistance arteries are contrasted to those obtained in other vascular beds. We provide examples of therapeutic attempts, such as use of statins, ACE inhibitors and insulin sensitizers to prevent obesity-related microvascular complications. We further identify some of the important challenges and opportunities going forward.
引用
收藏
页码:544 / 560
页数:17
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