Intensity-modulated radiosurgery for childhood arteriovenous malformations

被引:9
作者
Fuss, M
Salter, BJ
Caron, JL
Vollmer, DG
Herman, TS
机构
[1] Univ Texas, Hlth Sci Ctr, Dept Radiat Oncol, San Antonio, TX 78229 USA
[2] Univ Texas, Hlth Sci Ctr, Ctr Neurol Sci, San Antonio, TX USA
[3] Canc Therapy & Res Ctr S Texas, San Antonio, TX 78229 USA
[4] Univ Texas, Dept Neurosurg, Houston, TX USA
关键词
intensity-modulated radiosurgery (IMRS); arterio-venous malformation (AVM); pediatric AVM; dosimetric parameter; outcome;
D O I
10.1007/s00701-005-0572-9
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose. Presentation of intensity-modulated radiosurgery (IMRS) for the treatment of inoperable, complex shaped pediatric arterio-venous malformations AVM. Method. Between 03/99 and 11/04, IMRS was delivered to seven children aged six to 18 years. Prescribed minimum doses ranged from 17.5 to 20 Gy (median 18 Gy). Radiosurgery planning and delivery used a serial tomotherapeutic IMRT technique ( Peacock IMRT, North American Scientific/Nomos, Cranberry Township, PA) over two to four couch angles. A linear accelerator attached binary multi-leaf collimator was used to generate pencil beams of 10 mm by either 8.5 or 4.0 mm. Treatment planning employed an inverse treatment planning optimization algorithm. Parameters submitted to the treatment planning system were: prescription dose (PD), volume of target allowed to receive less dose (standard 3%), minimum dose (0.5 Gy less than PD), and maximum dose (200% of PD). Planning system specific IMRS target and tissue types were selected to prioritize dose conformality over dose homogeneity. The prescription isodose encompassed at least 95% of the target volume. We calculated conformality (CI) and homogeneity indices (HI) to characterize the quality of IMRS plans, and summarized preliminary clinical outcomes. Findings. Target volumes ranged from 0.71 to 63.02 cm(3) (median 13.8 cm(3), 6/7 AVM larger than 10 cm(3)). Median CI was 1.07 (range 1.05 to 1.7) according to RTOG criteria. Median HI was 1.12 (range 1.09 to 1.23). During limited follow-up (median 32 months, range 5 to 53 months), two AVM completely obliterated at 19 and 22 months, and partial obliteration (> 75%) was observed in three cases. No treatment-related side effects, other than acute nausea and temporary headaches interpreted as being associated with changes in cerebral blood distribution, were observed. Conclusions. IMRS can allow for highly conformal planning and delivery of radiosurgery radiation doses even if pediatric AVM target volumes are large and/or highly complex in shape. This technique has been seen to result in favorable preliminary outcomes, thus supporting future exploration of this technique in pediatric and adult patients.
引用
收藏
页码:1141 / 1150
页数:10
相关论文
共 28 条
[1]   GAMMA-KNIFE RADIOSURGERY FOR INTRACRANIAL ARTERIOVENOUS-MALFORMATIONS IN CHILDHOOD AND ADOLESCENCE [J].
ALTSCHULER, EM ;
LUNSFORD, LD ;
COFFEY, RJ ;
BISSONETTE, DJ ;
FLICKINGER, JC .
PEDIATRIC NEUROSCIENCE, 1989, 15 (02) :53-61
[2]   Intensity-modulated stereotactic radiosurgery using dynamic micro-multileaf collimation [J].
Benedict, SH ;
Cardinale, RM ;
Wu, QW ;
Zwicker, RD ;
Broaddus, WC ;
Mohan, R .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 50 (03) :751-758
[3]   A quality factor to compare the dosimetry of gamma knife radiosurgery and intensity-modulated radiation therapy quantitatively as a function of target volume and shape - Technical note [J].
Borden, JA ;
Mahajan, A ;
Tsai, JS .
JOURNAL OF NEUROSURGERY, 2000, 93 :228-232
[4]   A comparison of three stereotactic radiotherapy techniques; arcs vs. noncoplanar fixed fields vs. intensity modulation [J].
Cardinale, RM ;
Benedict, SH ;
Wu, QW ;
Zwicker, RD ;
Gaballa, HE ;
Mohan, R .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 42 (02) :431-436
[5]   Cerebral arteriovenous malformations in children [J].
Di Rocco, C ;
Tamburrini, G ;
Rollo, M .
ACTA NEUROCHIRURGICA, 2000, 142 (02) :145-+
[6]  
DIROCCO C, 2000, ACTA NEUROCHIR WIEN, V142, P56
[7]   Full scale IQ (FSIQ) changes in children treated with whole brain and partial brain irradiation - A review and analysis [J].
Fuss, M ;
Poljanc, K ;
Hug, EB .
STRAHLENTHERAPIE UND ONKOLOGIE, 2000, 176 (12) :573-581
[8]   CEREBRAL ARTERIOVENOUS-MALFORMATIONS IN CHILDREN AND ADOLESCENTS [J].
GARZAMERCADO, R ;
CAVAZOS, E ;
TAMEZMONTES, D .
SURGICAL NEUROLOGY, 1987, 27 (02) :131-140
[9]   Multimodality treatment of nongalenic arteriovenous malformations in pediatric patients [J].
Hoh, BL ;
Ogilvy, CS ;
Butler, WE ;
Loeffler, JS ;
Putman, CM ;
Chapman, PH .
NEUROSURGERY, 2000, 47 (02) :346-357
[10]  
Kramer B A, 1998, Radiat Oncol Investig, V6, P18, DOI 10.1002/(SICI)1520-6823(1998)6:1<18::AID-ROI3>3.3.CO