Biological mechanisms involved in the spread of traumatic brain damage

被引:47
作者
Rovegno, M. [2 ,3 ]
Soto, P. A. [3 ]
Saez, J. C. [3 ]
von Bernhardi, R. [1 ]
机构
[1] Pontificia Univ Catolica Chile, Fac Med, Dept Neurol, Lab Neurociencias, Santiago, Chile
[2] Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile
[3] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Fisiol, Santiago, Chile
关键词
Apoptosis; Brain injury; Excitotoxicity; Neuroinflammation; Neuroglia; Traumatic brain injury; GAP-JUNCTION HEMICHANNELS; APOPTOTIC CELL-DEATH; SEVERE HEAD-INJURY; CYCLOSPORINE-A; IN-VIVO; CONNEXIN-43; HEMICHANNELS; CONTROLLED-TRIAL; CLINICAL-TRIALS; RAT-BRAIN; ASTROCYTES;
D O I
10.1016/j.medin.2011.06.008
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Traumatic brain injury (TBI) is a worldwide health problem that is especially prevalent in young adults. It is characterized by one or more primary injury foci, with secondary spread to initially not compromised areas via cascades of inflammatory response, excitotoxicity, energy failure conditions, and amplification of the original tissue injury by glia. In theory, such progression of injury should be amenable to management. However, all neuroprotective drug trials have failed, and specific treatments remain lacking. These negative results can be explained by a neuron centered approach, excluding the participation of other cell types and pathogenic mechanisms. To change this situation, it is necessary to secure a better understanding of the biological mechanisms determining damage progression or spread. We discuss the biological mechanisms involved in the progression of post-trauma tissue damage, including the general physiopathology of TBI and cellular mechanisms of secondary damage such as inflammation, apoptosis, cell tumefaction, excitotoxicity, and the role of glia in damage propagation. We highlight the role of glia in each cellular mechanism discussed. Therapeutic approaches related to the described mechanisms have been included. The discussion is completed with a working model showing the convergence of the main topics. (C) 2011 Elsevier Espana, S.L. and SEMICYUC. All rights reserved.
引用
收藏
页码:37 / 44
页数:8
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