Fluoroalkyl substituted (Z)-dehydro α-amino ester as a building block for the fluorine-containing cyclopropyl α-amino esters and dihydrooxazole

被引：22

作者：

Wan, Wen ^{[1
]}

Gao, Yinghong ^{[1
]}

Jiang, Haizhen ^{[1
]}

Hao, Jian ^{[1
,2
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2008年 / 129卷 / 06期

基金：

中国国家自然科学基金;

关键词：

dehydro amino acids; fluorine-containing building blocks; fluorine-containing cylcopropyl amino; acids; cycloadditions; dihydrooxazoles;

D O I：

10.1016/j.jfluchem.2008.03.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Multi-functionalized beta-trifluoromethyl and beta-difluoromethyl substituted (Z)-alpha,beta-dehydro alpha-amino esters have been successfully prepared from N-protected fluorinated threonine ester. Applications of this new fluorine-containing building block to the synthesis of biologically important fluorinated cylcopropyl alpha-amino esters and dihydrooxazole ester have also been reported. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：510 / 514

页数：5

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