A Novel Strategy for Dissecting Goal-Directed Action and Arousal Components of Motivated Behavior With a Progressive Hold-Down Task

被引:34
作者
Bailey, Matthew R. [1 ]
Jensen, Greg [1 ]
Taylor, Kathleen [2 ,3 ]
Mezias, Chris [4 ]
Williamson, Cait [1 ]
Silver, Rae [4 ,5 ]
Simpson, Eleanor H. [2 ,3 ]
Balsam, Peter D. [2 ,4 ]
机构
[1] Columbia Univ, Dept Psychol, New York, NY 10032 USA
[2] Columbia Univ, Dept Psychiat, New York, NY 10032 USA
[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[4] Columbia Univ Barnard Coll, Dept Psychol, New York, NY 10027 USA
[5] Columbia Univ, New York, NY 10032 USA
基金
美国国家科学基金会;
关键词
motivation; progressive ratio; progressive hold down; arousal; goal-directed action; RATIO PERFORMANCE; ACCUMBENS DOPAMINE; LOCOMOTOR-ACTIVITY; FOOD REWARD; APATHY; AMPHETAMINE; DEPRESSION; STRIATUM; MICE; METHAMPHETAMINE;
D O I
10.1037/bne0000060
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Motivation serves 2 important functions: It guides actions to be goal-directed, and it provides the energy and vigor required to perform the work necessary to meet those goals. Dissociating these 2 processes with existing behavioral assays has been a challenge. In this article, we report a novel experimental strategy to distinguish the 2 processes in mice. First, we characterize a novel motivation assay in which animals must hold down a lever for progressively longer intervals to earn each subsequent reward; we call this the progressive hold-down (PHD) task. We find that performance on the PHD task is sensitive to both food deprivation level and reward value. Next, we use a dose of methamphetamine (METH) 1.0 mg/kg, to evaluate behavior in both the progressive ratio (PR) and PHD tasks. Treatment with METH leads to more persistent lever pressing for food rewards in the PR. In the PHD task, we found that METH increased arousal, which leads to numerous bouts of hyperactive responding but neither increases nor impairs goal-directed action. The results demonstrate that these tools enable a more precise understanding of the underlying processes being altered in manipulations that alter motivated behavior.
引用
收藏
页码:269 / 280
页数:12
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