Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review

被引:10
作者
Bonavides Amaral, Maria Eduarda [1 ]
Ejzenberg, Dani [1 ]
Wajman, Denis Schapira [1 ]
Araujo Monteleone, Pedro Augusto [1 ]
Serafini, Paulo [1 ]
Soares, Jose Maria, Jr. [1 ]
Baracat, Edmund Chada [1 ]
机构
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Disciplina Ginecol,Dept Obstet & Ginecol, Av Dr Eneas de Carvalho Aguiar 255, BR-05403000 Sao Paulo, SP, Brazil
关键词
Poor response; Poor responder; Human reproduction; Assisted reproduction; In vitro fertilization; Bologna criteria; POR; ART; IN-VITRO FERTILIZATION; ANTI-MULLERIAN HORMONE; BODY-MASS INDEX; BISPHENOL-A CONCENTRATIONS; LIVE BIRTH-RATES; ANTIMULLERIAN HORMONE; BLOOD-TYPE; BOLOGNA CRITERIA; POOR RESPONDERS; SUBCLINICAL HYPOTHYROIDISM;
D O I
10.1007/s10815-018-1324-0
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
PurposeControlled ovarian stimulation is a fundamental part of a successful assisted reproduction treatment, and recognizing patients at risk of a poor response allows the development of targeted research to propose new treatment strategies for this specific group. The objective of this systematic review was to determine risk factors for poor ovarian response (POR) to controlled stimulation in assisted reproduction cycles described in the literature.MethodsThe primary databases MEDLINE, Cochrane, LILACS, and SciELO were consulted, using specific terms with a restriction for articles in English or Portuguese published in the last 10years.Results and conclusionOur data suggest that environmental endocrine disruptors, tobacco, genetic mutations, endometriomas, ovarian surgery, chemotherapy, and short menstrual cycles are factors that influence stimulation in assisted reproduction cycles. Further studies are necessary for characterizing patients with prior risk factors.
引用
收藏
页码:19 / 28
页数:10
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