Plasma and Cerebrospinal Fluid Therapeutic Drug Monitoring of Ceftolozane and Tazobactam During Treatment of Multidrug-Resistant Pseudomonas aeruginosa Meningitis

被引：15
作者：
McCreary, Erin K. [1 ]
Byers, Karin E. [1 ]
Fernandes, Carolyn [1 ]
Kline, Ellen G. [1 ]
Nicolau, David P. [2 ]
Shields, Ryan K. [1 ]
机构：
[1] Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA 15213 USA
[2] Ctr Antiinfect Res & Dev, Hartford, CT USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 12期
关键词：
beta-lactamase inhibitor; central nervous system; difficult-to-treat; gram-negative; KLEBSIELLA-PNEUMONIAE; CEFTAZIDIME/AVIBACTAM; PENETRATION; INFECTIONS; BLOOD;
D O I：
10.1093/ofid/ofaa549
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We report a case of multidrug-resistant Pseudomonas aeruginosa meningitis treated with ceftolozane-tazobactam with concomitant therapeutic drug monitoring of plasma and cerebral spinal fluid. The data suggest that ceftolozane-tazobactam may be an option for select central nervous system infections; however, treatment decisions should be interpreted on a case-by-case basis.
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