Acute leukoencephalopathy after buprenorphine intoxication in a 2-year-old child

被引：9

作者：

Bellot, Blandine ^{[1
,2
]}

Michel, Fabrice ^{[1
,2
]}

Thomachot, Laurent ^{[1
]}

Chaumoitre, Kathia ^{[2
,3
]}

Battaglia, Fabrice ^{[4
]}

Lagier, Pierre ^{[1
]}

机构：

[1] Ctr Hosp Univ Nord, Assistance Publ Hop Marseille, Unite Reanimat Pediat & Neonatale & Brules Pediat, F-13915 Marseille 20, France

[2] Univ Aix Marseille 2, Fac Med Marseille, Marseille, France

[3] Ctr Hosp Univ Nord, Assistance Publ Hop Marseille, Serv Imagerie Med, F-13195 Marseille 20, France

[4] Ctr Hosp Univ Nord, Assistance Publ Hop Marseille, Serv Neurochirurg & Neurol, F-13915 Marseille 20, France

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2011年 / 15卷 / 04期

关键词：

Buprenorphine; Intoxication; Pediatrics; Leukoencephalopathy; INHALING HEROIN; INHALATION;

D O I：

10.1016/j.ejpn.2011.03.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Leukoencephalopathies have been reported after heroin inhalation or ingestion, and buprenorphine injection, but the physiopathology remains unclear. We report here the first case of leukoencephalopathy caused by buprenorphine ingestion in a 2-year-old child who was admitted for coma and fever. Due to technical problems, the toxicology screen was delayed, and infectious disease was first suspected. A brain MRI found bilateral and symmetric white matter damages in the cerebral hemispheres and the cerebellum. Rapid recovery and positive toxicology screen for buprenorphine on day 4 confirmed the diagnosis of acute intoxication. (C) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：368 / 371

页数：4

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