Chemical constituents from endophytic fungus Fusarium oxysporum

被引：87

作者：

Wang, Quan-Xin ^{[1
,2
]}

Li, Sai-Fei ^{[1
]}

Zhao, Feng ^{[3
]}

Dai, Huan-Qin ^{[1
]}

Bao, Li ^{[1
]}

Ding, Rong ^{[4
]}

Gao, Hao ^{[4
]}

Zhang, Li-Xin ^{[1
]}

Wen, Hua-An ^{[1
]}

Liu, Hong-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, Key Lab Systemat Mycol & Lichenol, Beijing 100090, Peoples R China

[2] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China

[3] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

[4] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 05期

关键词：

Fusarium oxysporum; Oxysporidinone analogues; Cytotoxicity; Antibacterial; SECONDARY METABOLITES; BEAUVERICIN; INHIBITORS; ANALOGS;

D O I：

10.1016/j.fitote.2011.04.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new oxysporidinone analogue (1) and a new 3-hydroxyl-2-piperidinone derivative (2), along with the known compounds (-)-4,6'-anhydrooxysporidinone (3), (+)-fusarinolic acid (4), gibepyrone D (5), beauvercin (6),cerevisterol (7). fusaruside (8), and (25,2'R,3R,3'E,4E,8E)-1-O-D-glucopyranosyl-2-N-(2'-hydroxy-3'-octadecenoyl)-3-hydroxy-9-methyl-4,8-sphingadienine (9) were isolated from Fusarium oxysporum. Compounds 1-9 were evaluated for cytotoxicity using the MTT method against cancer cell lines, PC-3, PANC-1, and A549. Beauvericin showed cytotoxicity against PC-3, PANC-1, and A549 with IC(50) value of 49.5 +/- 3.8, 47.2 +/- 2.9, and 10.4 +/- 1.6 mu M, respectively. Beauvericin also exhibited anti-bacterial activity towards methicillin-resistant Staphylococcus aureus (MIC = 3.125 mu g/mL) and Bacillus subtilis (MIC = 3.125 mu g/mL). (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：777 / 781

页数：5

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