p53 Pro-Oxidant Activity in the Central Nervous System: Implication in Aging and Neurodegenerative Diseases

被引：34

作者：

Chatoo, Wassim ^{[1
]}

Abdouh, Mohamed ^{[1
]}

Bernier, Gilbert ^{[1
,2
]}

机构：

[1] Maisonneuve Rosemont Hosp, Dev Biol Lab, Montreal, PQ H1T 2M4, Canada

[2] Univ Montreal, Dept Ophthalmol, Montreal, PQ, Canada

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 15卷 / 06期

基金：

加拿大健康研究院;

关键词：

NEURONAL CELL-DEATH; NEURAL STEM-CELLS; TRANSCRIPTIONAL REPRESSION; TUMOR-SUPPRESSOR; OXIDATIVE STRESS; GENE-EXPRESSION; DNA-DAMAGE; LIFE-SPAN; P53-INDUCED APOPTOSIS; PARKINSONS-DISEASE;

D O I：

10.1089/ars.2010.3610

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in delineating the biological functions of p53 had shed the light on its key role in the multifacets of cellular homeostasis. After its activation, via DNA damage, oxidative stress, or aberrant expression of oncogenes, p53 transduces its classical effect through several mechanisms comprising activation of the DNA repair machinery, cell cycle arrest, and initiation of apoptosis or senescence. In the mammalian brain, p53 plays critical functions in normal development, tumor suppression, neurodegenerative diseases, and aging. Herein, we focus on the constitutive pro-oxidant activity of p53 in neurons and discuss the potential implication of this finding in the context of neurodegenerative diseases and normal brain aging. Antioxid. Redox Signal. 15, 1729-1737.

引用

页码：1729 / 1737

页数：9

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