How the "Melting" and "Freezing" of protein molecules may be used in cell signaling

被引：6

作者：

Bray, Dennis ^{[1
]}

Williams, Dudley ^{[2
]}

机构：

[1] Univ Cambridge, Cambridge CB2 3DY, England

[2] Dept Chem, Cambridge CB1 2EW, England

来源：

ACS CHEMICAL BIOLOGY | 2008年 / 3卷 / 02期

关键词：

D O I：

10.1021/cb800024g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The motile response of Escherichia coli bacteria to attractants and repellents is one of the best-understood examples of a signal transduction pathway. A number of recent studies suggest that the receptors in this system undergo major changes in both their degree of structural order and their state of aggregation in the membrane. We discuss the thermodynamic basis for this effect and argue that the '' freezing '' or '' melting '' of protein structure may be the language of signaling.

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收藏

页码：89 / 91

页数：3

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