Immunohistochemical examination of effects of kefir, koumiss and commercial probiotic capsules on platelet derived growth factor-c and platelet derived growth factor receptor-alpha expression in mouse liver and kidney

被引：9

作者：

Bakir, B. ^{[1
]}

Sari, E. K. ^{[2
]}

Aydin, B. D. ^{[3
]}

Yildiz, S. E. ^{[4
]}

机构：

[1] Univ Namik Kemal, Hlth Serv Vocat Sch, TR-59000 Tekirdag, Turkey

[2] Kafkas Univ, Fac Vet Med, Dept Histol Embryol, TR-36040 Kars, Turkey

[3] Directorate Food Agr & Livestock, TR-21000 Diyarbakir, Turkey

[4] Kafkas Univ, Sch Hlth Sci, TR-36040 Kars, Turkey

来源：

BIOTECHNIC & HISTOCHEMISTRY | 2015年 / 90卷 / 03期

关键词：

kefir; kidney; koumiss; liver; PDGF-C; PDGFR-alpha; probiotic; PDGF-C; MILK-KEFIR;

D O I：

10.3109/10520295.2014.976841

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We investigated using immunohistochemistry the effects of kefir, koumiss and commercial probiotic capsules on the expression of platelet derived growth factor-c (PDGF-C) and platelet derived growth factor receptor-alpha (PDGFR-alpha) in mouse liver and kidney. Mice were assigned to four groups: group 1 was given commercial probiotic capsules, group 2 was given kefir, group 3 was given koumiss and group 4 was untreated. After oral administration for 15 days, body weights were recorded and liver and kidney tissue samples were obtained. Hematoxylin and eosin staining was used to examine histology. PDGF-C and PDGFR-alpha in liver and kidney were localized using the streptavidin-biotin peroxidase complex method (ABC). We found that the weights of the mice in the kefir, koumiss and commercial probiotic capsules groups increased compared to the control group. No differences in liver and kidney histology were observed in any of the experimental groups. Kefir, koumiss and the commercial probiotic preparation increased PDGF-C and PDGFR-alpha expression.

引用

页码：190 / 196

页数：7

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