Nanoparticles: Emerging carriers for drug delivery

被引:349
作者
Mudshinge, Sagar R. [2 ]
Deore, Amol B. [3 ]
Patil, Sachin [4 ]
Bhalgat, Chetan M. [1 ]
机构
[1] SAC Coll Pharm, Nagamangala Tq, Karnataka, India
[2] NDMVPs Coll Pharm, Nasik 422005, Maharashtra, India
[3] NDMVPs Inst Pharmaceut Sci, Nasik, Maharashtra, India
[4] Mayani Coll Pharm, Mayani, Maharashtra, India
关键词
Nanoparticles; Nanoscale; Biomacromolecular; Supramolecular; Diagnostics; Nanostructures; SOLID LIPID NANOPARTICLES; IRON-OXIDE NANOPARTICLES; POLYAMIDOAMINE PAMAM DENDRIMERS; IN-VITRO RELEASE; QUANTUM DOTS; SUPERPARAMAGNETIC NANOPARTICLES; TRANSDERMAL DELIVERY; ENERGY-TRANSFER; FLUORESCENT NANOCRYSTALS; BIOMEDICAL APPLICATIONS;
D O I
10.1016/j.jsps.2011.04.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The core objective of nanoparticles is to control and manipulate biomacromolecular constructs and supramolecular assemblies that are critical to living cells in order to improve the quality of human health. By definition, these constructs and assemblies are nanoscale and include entities such as drugs, proteins, DNA/RNA, viruses, cellular lipid bilayers, cellular receptor sites and antibody variable regions critical for immunology and are involved in events of nanoscale proportions. The emergence of such nanotherapeutics/diagnostics will allow a deeper understanding of human longevity and human ills that include cancer, cardiovascular disease and genetic disorders. A technology platform that provides a wide range of synthetic nanostructures that may be controlled as a function of size, shape and surface chemistry and scale to these nanotechnical dimensions will be a critical first step in developing appropriate tools and a scientific basis for understanding nanoparticles. (C) 2011 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码:129 / 141
页数:13
相关论文
共 177 条
[91]   LIPOSOME-INCORPORATED CIPROFLOXACIN IN TREATMENT OF MURINE SALMONELLOSIS [J].
MAGALLANES, M ;
DIJKSTRA, J ;
FIERER, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (11) :2293-2297
[92]   Anti-HIV properties of cationic fullerene derivatives [J].
Marchesan, S ;
Da Ros, T ;
Spalluto, G ;
Balzarini, J ;
Prato, M .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (15) :3615-3618
[93]   Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives [J].
Mashino, T ;
Shimotohno, K ;
Ikegami, N ;
Nishikawa, D ;
Okuda, K ;
Takahashi, K ;
Nakamura, S ;
Mochizuki, M .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (04) :1107-1109
[94]  
MATSUMURA Y, 1986, CANCER RES, V46, P6387
[95]   Quantum dot bioconjugates for imaging, labelling and sensing [J].
Medintz, IL ;
Uyeda, HT ;
Goldman, ER ;
Mattoussi, H .
NATURE MATERIALS, 2005, 4 (06) :435-446
[96]   Solid lipid nanoparticles -: Production, characterization and applications [J].
Mehnert, W ;
Mäder, K .
ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (2-3) :165-196
[97]   LHRH-functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI [J].
Meng, J. ;
Fan, J. ;
Galiana, G. ;
Branca, R. T. ;
Clasen, P. L. ;
Ma, S. ;
Zhou, J. ;
Leuschner, C. ;
Kumar, C. S. S. R. ;
Hormes, J. ;
Otiti, T. ;
Beye, A. C. ;
Harmer, M. P. ;
Kiely, C. J. ;
Warren, W. ;
Haataja, M. P. ;
Soboyejo, W. O. .
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2009, 29 (04) :1467-1479
[98]   Quantum dots for live cells, in vivo imaging, and diagnostics [J].
Michalet, X ;
Pinaud, FF ;
Bentolila, LA ;
Tsay, JM ;
Doose, S ;
Li, JJ ;
Sundaresan, G ;
Wu, AM ;
Gambhir, SS ;
Weiss, S .
SCIENCE, 2005, 307 (5709) :538-544
[99]   Liposomal formulation of netilmicin [J].
Mimoso, IM ;
Francisco, APG ;
Cruz, MEM .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 147 (01) :109-117
[100]  
MINARD KR, 2009, MAGNETIC PARTICLE IM, P1426