Universally applicable RNA membrane-based microneedle system for transdermal drug delivery

被引:17
作者
Kim, Dajeong [1 ]
Kim, Hyejin [1 ]
Lee, Peter C. W. [2 ]
Lee, Jong Bum [1 ]
机构
[1] Univ Seoul, Dept Chem Engn, Seoul 02504, South Korea
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Biomed Sci, Seoul 05505, South Korea
基金
新加坡国家研究基金会;
关键词
COATING FORMULATIONS; DNA; PATCHES; SELF; VACCINATION; COMBINATION; PLATFORM; ANTIGEN; DESIGN; ARRAYS;
D O I
10.1039/c9mh01838g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The transdermal delivery of functional biomolecules has been widely achieved by microneedles in a non-invasive manner. However, establishing a simple and universal way to assure a stable loading of a large number of drugs is still imperative, particularly for the delivery of nucleic acid-based drugs. To address this issue, here, we present a universally applicable RNA membrane-coating system as a novel platform to manufacture purpose-oriented microneedles. Customization of RNA membrane-based microneedles is realized by large surface area, high cargo capacity, and controllable material properties of the RNA membrane and 3D-printing of customized scaffold microneedles in a purpose-oriented manner. In addition, simple covering with the RNA membrane facilitates the fabrication of RNA-coated microneedles regardless of the configuration and material of the scaffold. This study demonstrates the successful delivery of RNA along with various types of drugs by purpose-oriented microneedles. Taken together, our approach provides a general route towards the fabrication of tailor-made microneedles for efficient transdermal drug delivery.
引用
收藏
页码:1317 / 1326
页数:10
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