Integrin regulation

被引：384

作者：

Ginsberg, MH ^{[1
]}

Partridge, A ^{[1
]}

Shattil, SJ ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.ceb.2005.08.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrin signaling is bidirectional. 'Inside-out' signals regulate integrin affinity for adhesive ligands, and ligand-dependent, 'outside-in' signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified. However, a key unresolved question is how integrins propagate signals across the plasma membrane.

引用

页码：509 / 516

页数：8

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