Synthesis of fused bicyclic imidazoles by sequential van Leusen/ring-closing metathesis reactions

被引：83

作者：

Gracias, V ^{[1
]}

Gasiecki, AF ^{[1
]}

Djuric, SW ^{[1
]}

机构：

[1] Abbott Labs, Sacffold Oriented Synth, Med Chem Technol, Abbott Pk, IL 60064 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 15期

关键词：

D O I：

10.1021/ol050852+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.

引用

页码：3183 / 3186

页数：4

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