Optical coherence tomography for ultrahigh resolution in vivo imaging

被引：818

作者：

Fujimoto, JG ^{[1
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA

来源：

NATURE BIOTECHNOLOGY | 2003年 / 21卷 / 11期

关键词：

D O I：

10.1038/nbt892

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Optical coherence tomography (OCT) is an emerging biomedical optical imaging technique that performs high-resolution, cross-sectional tomographic imaging of microstructure in biological systems. OCT can achieve image resolutions of 1-15 mum, one to two orders of magnitude finer than standard ultrasound. The image penetration depth of OCT is determined by the optical scattering and is up to 2-3 mm in tissue. OCT functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale. It is a promising imaging technology because it can provide images of tissue in situ and in real time, without the need for excision and processing of specimens.

引用

页码：1361 / 1367

页数：7

共 100 条

[71] Differential absorption imaging with optical coherence tomography [J].

Schmitt, JM ;

Xiang, SH ;

Yung, KM .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1998, 15 (09) :2288-2296

[72] Optical coherence tomography (OCT): A review [J].

Schmitt, JM .

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 1999, 5 (04) :1205-1215

[73] QUANTIFICATION OF NERVE-FIBER LAYER THICKNESS IN NORMAL AND GLAUCOMATOUS EYES USING OPTICAL COHERENCE TOMOGRAPHY - A PILOT-STUDY [J].

SCHUMAN, JS ;

HEE, MR ;

PULIAFITO, CA ;

WONG, C ;

PEDUTKLOIZMAN, T ;

LIN, CP ;

HERTZMARK, E ;

IZATT, JA ;

SWANSON, EA ;

FUJIMOTO, JG .

ARCHIVES OF OPHTHALMOLOGY, 1995, 113 (05) :586-596

[74] Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy [J].

Schuman, JS ;

Wollstein, G ;

Farra, T ;

Hertzmark, E ;

Aydin, A ;

Fujimoto, JG ;

Paunescu, LA .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2003, 135 (04) :504-512

[75] Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography [J].

Schuman, JS ;

PedutKloizman, T ;

Hertzmark, E ;

Hee, MR ;

Wilkins, JR ;

Coker, JG ;

Puliafito, CA ;

Fujimoto, JG ;

Swanson, EA .

OPHTHALMOLOGY, 1996, 103 (11) :1889-1898

[76] First in vivo optical coherence tomography in the human bile duct [J].

Seitz, U ;

Freund, J ;

Jaeckle, S ;

Feldchtein, E ;

Bohnacker, S ;

Thonke, F ;

Gladkova, N ;

Brand, B ;

Schröder, S ;

Soehendra, N .

ENDOSCOPY, 2001, 33 (12) :1018-1021

[77] In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa [J].

Sergeev, A. M. ;

Gelikonov, V. M. ;

Gelikonov, G. V. ;

Feldchtein, F. I. ;

Kuranov, R. V. ;

Gladkova, N. D. ;

Shakhova, N. M. ;

Snopova, L. B. ;

Shakhov, A. V. ;

Kuznetzova, I. A. ;

Denisenko, A. N. ;

Pochinko, V. V. ;

Chumakov, Yu. P. ;

Streltzova, O. S. .

OPTICS EXPRESS, 1997, 1 (13) :432-440

[78] Optical coherence tomography monitoring for laser surgery of laryngeal carcinoma [J].

Shakhov, AV ;

Terentjeva, AB ;

Kamensky, VA ;

Snopova, LB ;

Gelikonov, VM ;

Feldchtein, FI ;

Sergeev, AM .

JOURNAL OF SURGICAL ONCOLOGY, 2001, 77 (04) :253-258

[79] High-resolution endoscopic imaging of the GI tract using optical coherence tomography [J].

Sivak, MV ;

Kobayashi, K ;

Izatt, JA ;

Rollins, AM ;

Ung-runyawee, R ;

Chak, A ;

Wong, RCK ;

Isenberg, GA ;

Willis, J .

GASTROINTESTINAL ENDOSCOPY, 2000, 51 (04) :474-479

[80] HIGH-SPEED OPTICAL COHERENCE DOMAIN REFLECTOMETRY [J].

SWANSON, EA ;

HUANG, D ;

HEE, MR ;

FUJIMOTO, JG ;

LIN, CP ;

PULIAFITO, CA .

OPTICS LETTERS, 1992, 17 (02) :151-153

← 1 2 3 4 5 6 7 8 9 10 →