Chronic Pain and Hepatitis C Virus Infection in Opioid Dependent Injection Drug Users

被引：16

作者：

Tsui, Judith I. ^{[1
]}

Herman, Debra S. ^{[2
,3
]}

Kettavong, Malyna ^{[2
,3
]}

Anderson, Bradley J. ^{[2
,3
]}

Stein, Michael D. ^{[2
,3
]}

机构：

[1] Boston Univ, Sch Med, Boston Med Ctr, Boston, MA 02118 USA

[2] Brown Univ, Butler Hosp, Providence, RI 02912 USA

[3] Brown Univ, Warren Alpert Sch Med, Providence, RI 02912 USA

来源：

JOURNAL OF ADDICTIVE DISEASES | 2011年 / 30卷 / 02期

关键词：

Hepatitis C virus; injection drug use; chronic pain; pain hypersensitivity; NECROSIS-FACTOR-ALPHA; METHADONE-MAINTENANCE PATIENTS; DEPRESSIVE SYMPTOMS; PANIC DISORDER; HIV; PREVALENCE; INTERLEUKIN-6; ASSOCIATION; RESPONSES; INTOLERANCE;

D O I：

10.1080/10550887.2011.554775

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

It is unknown whether infection with hepatitis C is a risk factor for pain among people who have used injection drugs. Multivariate regression was used to determine whether hepatitis C was associated with greater likelihood of reporting significant chronic pain and discomfort intolerance in a cohort of 97 injection drug users dependent on opioids. Study results suggest that participants with hepatitis C may be more likely to experience chronic pain (aOR = 1.98; 95% confidence interval = 0.76 to 5.12, p= 0.16). Furthermore, hepatitis C was found to be associated with a higher discomfort intolerance scale score, reflecting intolerance to physical discomfort (= 2.34; 95% confidence interval = 0.06 to 4.62; p= 0.04). Hepatitis C may be a cause for chronic pain and discomfort intolerance that is overlooked among injection drug users dependent on opioids.

引用

页码：91 / 97

页数：7

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