THE CYCLIN-DEPENDENT KINASE 2 (CDK2) IS DISPENSABLE FOR LIVER REGENERATION IN MICE AND CAN BE SUBSTITUTED BY CYCLIN D-DEPENDENT KINASE ACTIVITY AND KINASE-INDEPENDENT FUNCTIONS OF CYCLIN E

被引:0
|
作者
Hu, Wei [1 ]
Nevzorova, Yulia [1 ]
Haas, Ute [1 ]
Barbacid, Mariano [2 ]
Trautwein, Christian [1 ]
Liedtke, Christian [1 ]
机构
[1] Univ Hosp Aachen, Dept Med 3, Aachen, Germany
[2] CNIO, Madrid, Spain
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
145
引用
收藏
页码:392A / 392A
页数:1
相关论文
共 50 条
  • [21] Up-regulation of cyclin-dependent kinase 4/Cyclin d2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
    Schmidt, BA
    Rose, A
    Steinhoff, C
    Strohmeyer, T
    Hartmann, M
    Ackermann, R
    CANCER RESEARCH, 2001, 61 (10) : 4214 - 4221
  • [22] A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response
    Audetat, K. Audrey
    Galbraith, Matthew D.
    Odell, Aaron T.
    Lee, Thomas
    Pandey, Ahwan
    Espinosa, Joaquin M.
    Dowell, Robin D.
    Taatjes, Dylan J.
    MOLECULAR AND CELLULAR BIOLOGY, 2017, 37 (13)
  • [23] Cyclin-dependent kinase activity is required for progesterone receptor function: Novel role for cyclin A/Cdk2 as a progesterone receptor coactivator
    Narayanan, R
    Adigun, AA
    Edwards, DP
    Weigel, NL
    MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (01) : 264 - 277
  • [24] 3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors
    Singh, Sanjeev Kumar
    Dessalew, Nigus
    Bharatam, Prasad V.
    MEDICINAL CHEMISTRY, 2007, 3 (01) : 75 - 84
  • [25] 3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors
    Singh, S. K.
    Dessalew, N.
    Bharatam, P. V.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (11) : 1310 - 1319
  • [26] Concurrent Deletion of Cyclin E1 and Cyclin-Dependent Kinase 2 in Hepatocytes Inhibits DNA Replication and Liver Regeneration in Mice
    Hu, Wei
    Nevzorova, Yulia A.
    Haas, Ute
    Moro, Nives
    Sicinski, Piotr
    Geng, Yan
    Barbacid, Mariano
    Trautwein, Christian
    Liedtke, Christian
    HEPATOLOGY, 2014, 59 (02) : 651 - 660
  • [27] Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma
    M Matsumoto
    M Furihata
    T Ishikawa
    Y Ohtsuki
    S Ogoshi
    British Journal of Cancer, 1999, 80 : 256 - 261
  • [28] Regulation of mammalian cyclin-dependent kinase 2
    Sheaff, RJ
    CELL CYCLE CONTROL, 1997, 283 : 173 - 193
  • [29] Phosphorylation of MCM3 Protein by Cyclin E/Cyclin-dependent Kinase 2 (Cdk2) Regulates Its Function in Cell Cycle
    Li, Junhui
    Deng, Min
    Wei, Qian
    Liu, Ting
    Tong, Xiaomei
    Ye, Xin
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (46) : 39776 - 39785
  • [30] Discovery of INCB123667, a potent and selective cyclin-dependent kinase 2 (CDK2) inhibitor for the treatment of cyclin E dysregulated cancers
    Wee, S.
    Ye, M.
    Lo, Y.
    Hansbury, M.
    Shin, N.
    Weber, M.
    Roman, V.
    Huo, L.
    Skaggs, H.
    Drake, K.
    Kapilashrami, K.
    Stump, K.
    Yang, J.
    Chand, S.
    Timmers, C.
    Hummel, J.
    Ye, Y.
    Zhang, G.
    Yang, Y. O.
    Covington, M.
    Wu, L.
    Koblish, H.
    Kim, S.
    EUROPEAN JOURNAL OF CANCER, 2022, 174 : S79 - S79