Asprosin: A Novel Player in Metabolic Diseases

被引：111
作者：
Yuan, Mingyang [1 ]
Li, Weidong [1 ]
Zhu, Yan [1 ]
Yu, Boyao [1 ]
Wu, Jing [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Endocrinol, Changsha, Peoples R China
[2] Hunan Engn Res Ctr Obes & Metab Complicat, Changsha, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷
基金：
中国国家自然科学基金;
关键词：
asprosin; metabolic diseases; diabetes; obesity; PCOS; CVD; FBN1;
D O I：
10.3389/fendo.2020.00064
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue during fasting. Asprosin plays a complex role in the central nervous system (CNS), peripheral tissues, and organs. It is involved in appetite, glucose metabolism, insulin resistance (IR), cell apoptosis, etc. In this review, we will summarize the newly discovered roles of asprosin in metabolic diseases including diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD), which may contribute to future clinical diagnosis and treatment.
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