Lung Cancer in Never Smokers

被引：27

作者：

Yang, Ping ^{[1
]}

机构：

[1] Mayo Clin, Dept Hlth Sci Res, Coll Med, Rochester, MN 55905 USA

来源：

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE | 2011年 / 32卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Lung cancer; never smokers; environmental risk factors; genetic predisposition; molecular target therapy; ENVIRONMENTAL TOBACCO-SMOKE; TYROSINE KINASE INHIBITORS; CHLAMYDIA-PNEUMONIAE INFECTION; IDIOPATHIC PULMONARY-FIBROSIS; FAVORABLE PROGNOSTIC-FACTORS; RECEPTOR GENE-MUTATIONS; GPC5; RS2352028; VARIANT; BRONCHIOLOALVEOLAR CARCINOMA; SUSCEPTIBILITY LOCUS; ALPHA(1)-ANTITRYPSIN DEFICIENCY;

D O I：

10.1055/s-0031-1272865

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Lung cancer in never smokers (LCINS) has lately been recognized as a unique disease based on rapidly gained knowledge from genomic changes to treatment responses. The focus of this article is on current knowledge and challenges with regard to LCINS expanded from recent reviews highlighting five areas: (1) distribution of LCINS by temporal trends, geographic regions, and populations; (2) three well-recognized environmental risk factors; (3) other plausible environmental risk factors; (4) prior chronic lung diseases and infectious diseases as risk factors; and (5) lifestyles as risk or protective factors. This article will also bring attention to recently published literature in two pioneering areas: (1) histological characteristics, clinical features with emerging new effective therapies, and social and psychological stigma; and (2) searching for susceptibility genes using integrated genomic approaches.

引用

页码：10 / 21

页数：12

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