Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression

被引：28

作者：

Liu, Yuhuan ^{[2
,3
]}

Hu, Jingjing ^{[3
]}

Shen, Wei ^{[2
]}

Wang, Jiaqi ^{[1
]}

Chen, Chao ^{[1
]}

Han, Jie ^{[2
]}

Zai, Dongxia ^{[2
]}

Cai, Zailong ^{[1
]}

Yu, Chaoqin ^{[2
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Clin Res Ctr, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Dept Chinese Tradit Med, Shanghai 200433, Peoples R China

[3] Second Mil Med Univ, Changhai Hosp, Dept Obstet & Gynecol, Shanghai 200433, Peoples R China

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 05期

基金：

中国国家自然科学基金;

关键词：

COX-2; promoter; endometrial stromal cells; endometriosis; peritoneal fluid; CYCLOOXYGENASE-2; EXPRESSION;

D O I：

10.1016/j.fertnstert.2010.11.039

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E-2 production were induced in those cells by increasing COX-2 promoter transcription activity, which could be attenuated by a specific p38MAPK inhibitor, suggesting a role for peritoneal fluid in the etiopathogenesis of endometriosis. (Fertil Steril (R) 2011;95:1836-8. (C)2011 by American Society for Reproductive Medicine.)

引用

页码：1836 / 1838

页数：3

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