Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study

被引:27
作者
Agnew-Blais, Jessica C. [1 ]
Wertz, Jasmin [2 ]
Arseneault, Louise [3 ]
Belsky, Daniel W. [4 ,5 ,6 ]
Danese, Andrea [3 ,7 ,8 ]
Pingault, Jean-Baptiste [9 ]
Polanczyk, Guilherme, V [10 ]
Sugden, Karen [6 ,11 ]
Williams, Benjamin [6 ,11 ]
Moffitt, Terrie E. [3 ,6 ,11 ]
机构
[1] Queen Mary Univ London, Sch Biol & Behav Sci, Dept Psychol, London, England
[2] Univ Edinburgh, Sch Philosophy Psychol & Language Sci, Dept Psychol, Edinburgh, Midlothian, Scotland
[3] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England
[4] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA
[5] Columbia Univ, Butler Columbia Aging Ctr, Mailman Sch Publ Hlth, New York, NY USA
[6] Univ Oslo, Promenta Ctr, Oslo, Norway
[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, London, England
[8] South London & Maudsley NHS Fdn Trust, Natl & Specialist Child Traumat Stress & Anxiety, London, England
[9] UCL, Div Psychol & Language Sci, Clin Educ & Hlth Psychol, London, England
[10] Univ Sao Paulo, Dept Psychiat, Med Sch, Sao Paulo, Brazil
[11] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA
基金
巴西圣保罗研究基金会; 英国医学研究理事会; 欧洲研究理事会;
关键词
ADHD; genetics; longitudinal studies; family factors; early life experience; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; POLYGENIC RISK; PSYCHOPATHOLOGY; METAANALYSIS; INVENTORY; BEHAVIOR; HOMES;
D O I
10.1111/jcpp.13659
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Background Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. Methods Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12 years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self-report at age 12. Genome-wide ADHD polygenic risk scores (PRS) were calculated for mothers (n = 880) and twins (n = 1,999); of these, n = 871 mothers and n = 1,925 children had information on children's ADHD and household chaos. Results Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene-environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene-environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. Conclusions Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures.
引用
收藏
页码:1153 / 1163
页数:11
相关论文
共 50 条
[21]   Living with ADHD: A Meta-Synthesis Review of Qualitative Research on Children's Experiences and Understanding of Their ADHD [J].
Ringer, Noam .
INTERNATIONAL JOURNAL OF DISABILITY DEVELOPMENT AND EDUCATION, 2020, 67 (02) :208-224
[22]   Symptoms of ADHD and Autism Spectrum Disorder Interactively Predict Children's Verbal Fluency [J].
Xing, Jiayin ;
Wei, Ran ;
Wang, Hui ;
Hua, Zihui ;
Tang, Xinzhou ;
Yi, Li ;
Li, Xue ;
Liu, Jing .
JOURNAL OF ATTENTION DISORDERS, 2024, 28 (07) :1092-1104
[23]   The Impact of Experience on Children's Understanding of ADHD [J].
McMenamy, Jannette M. ;
Perrin, Ellen C. .
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 2008, 29 (06) :483-492
[24]   Canadian parents and children's knowledge of ADHD [J].
Climie, Emma A. ;
Henley, Laura .
VULNERABLE CHILDREN AND YOUTH STUDIES, 2018, 13 (03) :266-275
[25]   Children's ADHD and Dysregulation Problems, DAT1 Genotype and Methylation, and their Interplay with Family Environment [J].
Marzilli, Eleonora ;
Cerniglia, Luca ;
Tambelli, Renata ;
Cimino, Silvia .
CHILD & YOUTH CARE FORUM, 2023, 52 (02) :371-399
[26]   Fathers with Childhood ADHD, Parenting, and Their Young Children's Behavior: Offspring of the Pittsburgh ADHD Longitudinal Study (PALS) [J].
Joseph, Heather M. ;
Kennedy, Traci M. ;
Gnagy, Elizabeth M. ;
Perlman, Susan B. ;
Pelham, William E., Jr. ;
Molina, Brooke S. G. .
CHILD PSYCHIATRY & HUMAN DEVELOPMENT, 2019, 50 (01) :35-44
[27]   The Children’s Attention Project: a community-based longitudinal study of children with ADHD and non-ADHD controls [J].
Emma Sciberras ;
Daryl Efron ;
Elizabeth J Schilpzand ;
Vicki Anderson ;
Brad Jongeling ;
Philip Hazell ;
Obioha C Ukoumunne ;
Jan M Nicholson .
BMC Psychiatry, 13
[28]   Instability in Teacher Ratings of Children's Inattentive Symptoms Implications for the Assessment of ADHD [J].
Rabiner, David L. ;
Murray, Desiree W. ;
Rosen, Lisa ;
Hardy, Kristina ;
Skinner, Ann ;
Underwood, Marion .
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 2010, 31 (03) :175-180
[29]   The Children's Attention Project: a community-based longitudinal study of children with ADHD and non-ADHD controls [J].
Sciberras, Emma ;
Efron, Daryl ;
Schilpzand, Elizabeth J. ;
Anderson, Vicki ;
Jongeling, Brad ;
Hazell, Philip ;
Ukoumunne, Obioha C. ;
Nicholson, Jan M. .
BMC PSYCHIATRY, 2013, 13
[30]   Maternal Stress during Pregnancy, ADHD Symptomatology in Children and Genotype: Gene-Environment Interaction [J].
Grizenko, Natalie ;
Fortier, Marie-Eve ;
Zadorozny, Christin ;
Thakur, Geeta ;
Schmitz, Norbert ;
Duval, Renaud ;
Joober, Ridha .
JOURNAL OF THE CANADIAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2012, 21 (01) :9-15