Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

被引：13

作者：

Ferrauto, Giuseppe ^{[1
]}

Carniato, Fabio ^{[2
]}

Di Gregorio, Enza ^{[1
]}

Botta, Mauro ^{[2
]}

Tei, Lorenzo ^{[2
]}

机构：

[1] Univ Turin, Dept Mol Biotechnol & Hlth Sci, Via Nizza 52, I-10126 Turin, Italy

[2] Univ Piemonte Orientale, Dept Sci & Technol Innovat, Viale T Michel 11, I-15121 Alessandria, Italy

来源：

NANOSCALE | 2019年 / 11卷 / 39期

基金：

欧盟地平线“2020”;

关键词：

HUMAN SERUM-ALBUMIN; INDOCYANINE GREEN; CONTRAST AGENTS; THERAPY;

D O I：

10.1039/c9nr06524e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.

引用

页码：18031 / 18036

页数：6

共 36 条

[1] Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT) [J].

Beziere, Nicolas ;

Lozano, Neus ;

Nunes, Antonio ;

Salichs, Juan ;

Queiros, Daniel ;

Kostarelos, Kostas ;

Ntziachristos, Vasilis .

BIOMATERIALS, 2015, 37 :415-424

[2]

Bongsu J., 2014, IEEE J QUANTUM ELECT, V20, P149

[3] Molecular Photoacoustic Contrast Agents: Design Principles & Applications [J].

Borg, Raymond E. ;

Rochford, Jonathan .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2018, 94 (06) :1175-1209

[4] Gd-Based Mesoporous Silica Nanoparticles as MRI Probes [J].

Carniato, Fabio ;

Tei, Lorenzo ;

Botta, Mauro .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2018, (46) :4936-4954

[5] Selective functionalization of mesoporous silica nanoparticles with ibuprofen and Gd(III) chelates: a new probe for potential theranostic applications [J].

Carniato, Fabio ;

Munoz-Ubeda, Monica ;

Tei, Lorenzo ;

Botta, Mauro .

DALTON TRANSACTIONS, 2015, 44 (41) :17927-17931

[6] Functional Mesoporous Silica Nanocomposites: Biomedical Applications and Biosafety [J].

Castillo, Rafael R. ;

Vallet-Regi, Maria .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (04)

[7] Family of Enhanced Photoacoustic Imaging Agents for High-Sensitivity and Multiplexing Studies in Living Mice [J].

de la Zerda, Adam ;

Bodapati, Sunil ;

Teed, Robert ;

May, Salomon Y. ;

Tabakman, Scott M. ;

Liu, Zhuang ;

Khuri-Yakub, Butrus T. ;

Chen, Xiaoyuan ;

Dai, Hongjie ;

Gambhir, Sanjiv S. .

ACS NANO, 2012, 6 (06) :4694-4701

[8]

Enache M, 2010, REV ROUM CHIM, V55, P255

[9] Mitoxantrone, More than Just Another Topoisomerase II Poison [J].

Evison, Benny J. ;

Sleebs, Brad E. ;

Watson, Keith G. ;

Phillips, Don R. ;

Cutts, Suzanne M. .

MEDICINAL RESEARCH REVIEWS, 2016, 36 (02) :248-299

[10]

Fabrice P., 2011, J BIOMED OPT, V16

← 1 2 3 4 →