The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans-A Randomized Placebo-Controlled Study

被引:4
作者
Kozan, Pinar [1 ,2 ]
Blythe, Jackson C. [1 ,3 ]
Greenfield, Jerry R. [1 ,2 ,4 ]
Samocha-Bonet, Dorit [1 ,3 ]
机构
[1] Garvan Inst Med Res, Diabet & Metab Div, 384 Victoria St, Darlinghurst, NSW 2010, Australia
[2] Univ New South Wales, St Vincents Clin Sch, Fac Med, St Vincents Hosp, Level 5 deLacy Bldg,Victoria St, Darlinghurst, NSW 2010, Australia
[3] Univ New South Wales, Sch Med Sci, Fac Med, 18 High St, Sydney, NSW 2052, Australia
[4] St Vincents Hosp, Dept Endocrinol, 390 Victoria St, Darlinghurst, NSW 2010, Australia
关键词
alkaline diet; dietary acid load; type; 2; diabetes; acid-base homeostasis; sodium bicarbonate; postprandial glycaemia; INSULIN-RESISTANCE; SERUM BICARBONATE; RISK; NUTRITION; KIDNEY; DIET; AUGMENTATION; SENSITIVITY; HEALTH;
D O I
10.3390/nu9080861
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: High dietary acid load relates to increased risk of type 2 diabetes in epidemiological studies. We aimed to investigate whether buffering a high acid load meal with an alkalizing treatment changes glucose metabolism post meal. Methods: Non-diabetic participants (n = 32) were randomized to receive either 1680 mg NaHCO3 or placebo, followed by a high acid load meal in a double-blind placebo-controlled crossover (1-4 weeks apart) study. Thirty (20 men) participants completed the study. Venous blood pH, serum bicarbonate, blood glucose, serum insulin, C-peptide, non-esterified fatty acid (NEFA), and plasma glucagon-like peptide-1 (GLP-1) concentrations were measured at baseline (fasting) and at 15-30 min intervals for 3 h post meal. Results: The treatment was well tolerated. Venous blood pH declined in the first 15 min post meal with the placebo (p = 0.001), but not with NaHCO3 (p = 0.86) and remained decreased with the placebo for 3 h (pinteraction = 0.04). On average over the 3 h blood pH iAUC was greater with NaHCO3 compared with placebo (p = 0.02). However, postprandial glucose, insulin, C-peptide, NEFA and GLP-1 were not different between treatments (pinteraction >= 0.07). Conclusions: An alkalizing medication administered pre-meal has no acute effect on glycaemia and insulin response in healthy individuals. Long-term interventions in at-risk populations are necessary to investigate the effect of sustained alkalization on glucose metabolism.
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