Tumorigenesis: Twist1 links EMT to self-renewal

被引：79
|
作者：
Martin, Alberto [1 ,2 ]
Cano, Amparo [1 ,2 ]
机构：
[1] Univ Autonoma Madrid, Fac Med, Dept Bioquim, IdiPAZ, E-28029 Madrid, Spain
[2] Univ Autonoma Madrid, Inst Invest Biomed Alberto Sols, CSIC, E-28029 Madrid, Spain
来源：
NATURE CELL BIOLOGY | 2010年 / 12卷 / 10期
关键词：
CANCER STEM-CELLS; SENESCENCE; BMI1;
D O I：
10.1038/ncb1010-924
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The epithelial-mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. a molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1.
引用
收藏
页码：924 / 925
页数：2
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