Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives

被引：13

作者：

Guo, Xin ^{[1
,2
,3
]}

Li, Yi Liang ^{[1
,2
,4
]}

Liu, Yu Fei ^{[5
]}

Guo, Hui Yuan ^{[1
,2
]}

Wang, Yu Cheng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China

[4] Tianjin Inst Pharmaceut Res, Tianjin Key Lab Mol Design & Drug Discovery, Tianjin 300193, Peoples R China

[5] Xuzhou Med Coll, Xuzhou 221004, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 10期

关键词：

Fluoroquinolone; Synthesis; Antibacterial activities; QUINOLONE ANTIBACTERIAL; AGENTS;

D O I：

10.1016/j.cclet.2010.06.011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 6g, 7g and 7h with the potencies similar to those of gemifloxacin, moxifloxacin, gatifloxacin and levofloxacin against Gram-positive organisms, worth further investigation. (C) 2010 Yu Cheng Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1141 / 1144

页数：4

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