Ethical rejections of xenotransplantation? The potential and challenges of using human-pig chimeras to create organs for transplantation

被引:21
作者
Loike, John D. [1 ]
Kadish, Alan [2 ]
机构
[1] Touro Coll, Biol, New York, NY 10010 USA
[2] Touro Coll & Univ Syst, New York, NY USA
关键词
TRANSPLANTATION;
D O I
10.15252/embr.201846337
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Xenotransplantation using organs from human‐pig chimeras has great potential to alleviate the shortage of donor organs and benefit patients. However, scientific, ethical and financial issues need to be resolved before clinical testing can begin. [graphic not available: see fulltext]
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页数:4
相关论文
共 10 条
[1]   Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts [J].
Iwase, Hayato ;
Hara, Hidetaka ;
Ezzelarab, Mohamed ;
Li, Tao ;
Zhang, Zhongqiang ;
Gao, Bingsi ;
Liu, Hong ;
Long, Cassandra ;
Wang, Yi ;
Cassano, Amy ;
Klein, Edwin ;
Phelps, Carol ;
Ayares, David ;
Humar, Abhinav ;
Wijkstrom, Martin ;
Cooper, David K. C. .
XENOTRANSPLANTATION, 2017, 24 (02)
[2]   Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future [J].
Liu, Zhengzhao ;
Hu, Wenbao ;
He, Tian ;
Dai, Yifan ;
Hara, Hidetaka ;
Bottino, Rita ;
Cooper, David K. C. ;
Cai, Zhiming ;
Mou, Lisha .
CELL TRANSPLANTATION, 2017, 26 (06) :925-947
[3]   High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell Transplantation for Relapsing-Remitting Multiple Sclerosis (HALT-MS) A 3-Year Interim Report [J].
Nash, Richard A. ;
Hutton, George J. ;
Racke, Michael K. ;
Popat, Uday ;
Devine, Steven M. ;
Griffith, Linda M. ;
Muraro, Paolo A. ;
Openshaw, Harry ;
Sayre, Peter H. ;
Stueve, Olaf ;
Arnold, Douglas L. ;
Spychala, Meagan E. ;
McConville, Kaitlyn C. ;
Harris, Kristina M. ;
Phippard, Deborah ;
Georges, George E. ;
Wundes, Annette ;
Kraft, George H. ;
Bowen, James D. .
JAMA NEUROLOGY, 2015, 72 (02) :159-169
[4]   Xenogeneic chimera-Generated by blastocyst complementation-As a potential unlimited source of recipient-tailored organs [J].
Oldani, Graziano ;
Peloso, Andrea ;
Lacotte, Stephanie ;
Meier, Raphael ;
Toso, Christian .
XENOTRANSPLANTATION, 2017, 24 (04)
[5]   Jewish, Christian and Muslim theological perspectives about xenotransplantation [J].
Paris, Wayne ;
Seidler, Rabbi Jerry H. ;
FitzGerald, Kevin ;
Padela, Aasim I. ;
Cozzi, Emanuele ;
Cooper, David K. C. .
XENOTRANSPLANTATION, 2018, 25 (03)
[6]  
Rapp N, 2017, FORTUNE
[7]  
Rosner F, 1999, MT SINAI J MED, V66, P314
[8]  
Sawai T, 2017, REGEN MED, V12, P233, DOI 10.2217/rme-2016-0171
[9]   Interspecies Chimerism with Mammalian Pluripotent Stem Cells [J].
Wu, Jun ;
Platero-Luengo, Aida ;
Sakurai, Masahiro ;
Sugawara, Atsushi ;
Antonia Gil, Maria ;
Yamauchi, Takayoshi ;
Suzuki, Keiichiro ;
Bogliotti, Yanina Soledad ;
Cuello, Cristina ;
Valencia, Mariana Morales ;
Okumura, Daiji ;
Luo, Jingping ;
Vilarino, Marcela ;
Parrilla, Inmaculada ;
Soto, Delia Alba ;
Martinez, Cristina A. ;
Hishida, Tomoaki ;
Sanchez-Bautista, Sonia ;
Llanos Martinez-Martinez, M. ;
Wang, Huili ;
Nohalez, Alicia ;
Aizawa, Emi ;
Martinez-Redondo, Paloma ;
Ocampo, Alejandro ;
Reddy, Pradeep ;
Roca, Jordi ;
Maga, Elizabeth A. ;
Esteban, Concepcion Rodriguez ;
Berggren, W. Travis ;
Nunez Delicado, Estrella ;
Lajara, Jeronimo ;
Guillen, Isabel ;
Guillen, Pedro ;
Campistol, Josep M. ;
Martinez, Emilio A. ;
Juan Ross, Pablo ;
Belmonte, Juan Carlos Izpisua .
CELL, 2017, 168 (03) :473-+
[10]   Interspecies organogenesis generates autologous functional islets [J].
Yamaguchi, Tomoyuki ;
Sato, Hideyuki ;
Kato-Itoh, Megumi ;
Goto, Teppei ;
Hara, Hiromasa ;
Sanbo, Makoto ;
Mizuno, Naoaki ;
Kobayashi, Toshihiro ;
Yanagida, Ayaka ;
Umino, Ayumi ;
Ota, Yasunori ;
Hamanaka, Sanae ;
Masaki, Hideki ;
Rashid, Sheikh Tamir ;
Hirabayashi, Masumi ;
Nakauchi, Hiromitsu .
NATURE, 2017, 542 (7640) :191-196