Benzothiazole-based fluorescence chemosensors for rapid recognition and "turn-off" fluorescence detection of Fe3+ ions in aqueous solution and in living cells

被引：63

作者：

Gong, Xue ^{[1
]}

Ding, Xin ^{[2
]}

Jiang, Nan ^{[1
]}

Zhong, Tianyuan ^{[1
]}

Wang, Guang ^{[1
]}

机构：

[1] Northeast Normal Univ, Fac Chem, Changchun 130024, Jilin, Peoples R China

[2] Inner Mongolia Univ Nationalities, Fac Chem & Chem Engn, Tongliao 028043, Peoples R China

来源：

MICROCHEMICAL JOURNAL | 2020年 / 152卷

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

Benzothiazole; Fluorescence sensors; Fe3+ ions; Cell imaging; COLORIMETRIC DETECTION; RATIOMETRIC DETECTION; HIGH SELECTIVITY; SENSOR; PROBE; CU2+; ZN2+; FRET; AL3+; PH;

D O I：

10.1016/j.microc.2019.104351

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two new benzothiazole-based fluorescence sensors (sensor 1 and sensor 2) have been successfully synthesized and their structures have been well characterized by H-1 NMR, C-13 NMR and mass spectrometry. Sensor 1 and sensor 2 displayed a selective fluorescence quenching response towards Fe3+ ions in aqueous solutions with good anti-interference ability. Sensor 1 and sensor 2 exhibited lower detection limits for Fe3+, 8.43 mu M for sensor 1 and 5.86 mu M for sensor 2, respectively. The Job's plot, mass spectrometry, H-1 NMR titration and DFT calculations proved that sensors formed 1:1 complexes with Fe3+ ions. In addition, sensor 1 and Sensor 2 had low cell toxicity and could be used to monitor the existence of Fe3+ ions in living cells.

引用

页数：10

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