Benzothiazole-based fluorescence chemosensors for rapid recognition and "turn-off" fluorescence detection of Fe3+ ions in aqueous solution and in living cells

被引：63
作者：
Gong, Xue [1 ]
Ding, Xin [2 ]
Jiang, Nan [1 ]
Zhong, Tianyuan [1 ]
Wang, Guang [1 ]
机构：
[1] Northeast Normal Univ, Fac Chem, Changchun 130024, Jilin, Peoples R China
[2] Inner Mongolia Univ Nationalities, Fac Chem & Chem Engn, Tongliao 028043, Peoples R China
来源：
MICROCHEMICAL JOURNAL | 2020年 / 152卷
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
Benzothiazole; Fluorescence sensors; Fe3+ ions; Cell imaging; COLORIMETRIC DETECTION; RATIOMETRIC DETECTION; HIGH SELECTIVITY; SENSOR; PROBE; CU2+; ZN2+; FRET; AL3+; PH;
D O I：
10.1016/j.microc.2019.104351
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Two new benzothiazole-based fluorescence sensors (sensor 1 and sensor 2) have been successfully synthesized and their structures have been well characterized by H-1 NMR, C-13 NMR and mass spectrometry. Sensor 1 and sensor 2 displayed a selective fluorescence quenching response towards Fe3+ ions in aqueous solutions with good anti-interference ability. Sensor 1 and sensor 2 exhibited lower detection limits for Fe3+, 8.43 mu M for sensor 1 and 5.86 mu M for sensor 2, respectively. The Job's plot, mass spectrometry, H-1 NMR titration and DFT calculations proved that sensors formed 1:1 complexes with Fe3+ ions. In addition, sensor 1 and Sensor 2 had low cell toxicity and could be used to monitor the existence of Fe3+ ions in living cells.
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页数：10
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