Performance Monitoring Local Field Potentials in the Medial Frontal Cortex of Primates: Supplementary Eye Field

Emeric EE, Leslie M, Pouget P, Schall JD. Performance monitoring local field potentials in the medial frontal cortex of primates: supplementary eye field. J Neurophysiol 104: 1523-1537, 2010. First published July 21, 2010; doi: 10.1152/jn.01001.2009. We describe intracranial local field potentials (LFPs) recorded in the supplementary eye field (SEF) of macaque monkeys performing a saccade countermanding task. The most prominent feature at 90% of the sites was a negative-going polarization evoked by a contralateral visual target. At roughly 50% of sites a negative-going polarization was observed preceding saccades, but in stop signal trials this polarization was not modulated in a manner sufficient to control saccade initiation. When saccades were canceled in stop signal trials, LFP modulation increased with the inferred magnitude of response conflict derived from the coactivation of gaze-shifting and gaze-holding neurons. At 30% of sites, a pronounced negative-going polarization occurred after errors. This negative polarity did not appear in unrewarded correct trials. Variations of response time with trial history were not related to any features of the LFP. The results provide new evidence that error-related and conflict-related but not feedback-related signals are conveyed by the LFP in the macaque SEF and are important for identifying the generator of the error-related negativity.