New palladium(II) complexes of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones: Synthesis, spectral studies and in vitro anti-amoebic activity

被引：87
作者：
Bharti, N [1 ]
Shailendra [1 ]
Sharma, S [1 ]
Naqvi, F [1 ]
Azam, A [1 ]
机构：
[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 13期
关键词：
D O I：
10.1016/S0968-0896(03)00213-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thiosemicarbazones (1-7) and their palladium(11) complexes (1a-7a) of the type [Pd(TSCN)Cl-2] (where TSCN = thiosemicarbazone) were prepared from 5-nitro thiophene-2-carboxaldehyde and [Pd(DMSO)(2)Cl-2], respectively. Coordination via the thionic sulphur and the azomethine nitrogen atom of the thiosemicarbazones to the metal ion were confirmed by spectral data. These compounds were screened in vitro against (HK-9) strain of Entamoeba histolytica possess amoebicidal properties. Enhancement of antiamoebic activity resulted due to the introduction of palladium metal in the thiosemicarbazone moiety. The most promising of the group tested are [Pd(5-N-2-TCA-COTSCN)Cl-2] and [Pd(5-N-2-TCA-AdmTSCN)Cl-2] comparable to that of metronidazole. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：2923 / 2929
页数：7
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