Palladium-Catalyzed Carbonylative Synthesis of N-Acetyl Benzoxazinones

被引：8

作者：

Qi, Xinxin ^{[1
]}

Li, Rui ^{[1
]}

Li, Hao-Peng ^{[1
]}

Peng, Jin-Bao ^{[1
]}

Ying, Jun ^{[1
]}

Wu, Xiao-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Xiasha Campus, Hangzhou 310018, Zhejiang, Peoples R China

[2] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

CHEMCATCHEM | 2018年 / 10卷 / 16期

关键词：

palladium; carbonylation; N-acetyl benzoxazinones; heterocycle synthesis; domino reaction; EXTERNAL CARBON-MONOXIDE; KHAND-TYPE REACTION; CO SOURCE; FORMIC-ACID; ARYL HALIDES; REDUCTIVE CARBONYLATION; ANTHRANILIC ACID; CONVENIENT; TRANSFORMATION; DERIVATIVES;

D O I：

10.1002/cctc.201800532

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A palladium-catalyzed intramolecular carbonylation reaction for the synthesis of N-acetyl benzoxazinones has been achieved for the first time. To avoid the using of toxic and flammable CO gas, formic acid was utilized as the CO source here. This carbonylative process is conducted under mild reaction conditions with high reaction efficiency. A variety of the desired N-acetyl benzoxazinone products were obtained in moderate to excellent yields with very good functional group compatibility. The presents of acid anhydride holds two roles here: formic acid activator and acyl source.

引用

页码：3415 / 3418

页数：4

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