Home-based exercise in autoimmune myasthenia gravis: A randomized controlled trial

被引：8

作者：

Birnbaum, S. ^{[1
]}

Porcher, R. ^{[2
]}

Portero, P. ^{[3
]}

Clair, B. ^{[4
]}

Demeret, S. ^{[4
]}

Eymard, B. ^{[5
]}

Gargiulo, M. ^{[1
]}

Louet, E. ^{[1
]}

Berrih-Aknin, S. ^{[1
]}

Le Panse, R. ^{[5
]}

Aegerter, P. ^{[4
]}

Hogrel, J. Y. ^{[1
]}

Sharshar, T. ^{[6
]}

机构：

[1] Inst Myol, Paris, France

[2] Hop Hotel Dieu, Clin Epidemiol Ctr, Paris, France

[3] Univ Paris Est, Creteil, France

[4] AP HP, Paris, France

[5] Paris Descartes Univ, Inst Psychol, Paris, France

[6] GHU Psychiat Neurosci, Hop St Anne, F-75014 Paris, France

来源：

NEUROMUSCULAR DISORDERS | 2021年 / 31卷 / 08期

关键词：

Myasthenia gravis; Exercise; Randomized controlled trial; Autoimmune disease; Quality of life; QUALITY-OF-LIFE; PSYCHOMETRIC PROPERTIES; ANXIETY; PEOPLE;

D O I：

10.1016/j.nmd.2021.05.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The tolerance of exercise and its effects on quality of life in myasthenia gravis are not currently backed up by strong evidence. The aim of this study was to determine whether exercise as an adjunct therapy is well tolerated and can improve health-related quality of life (HRQoL) in stabilized, generalized autoimmune myasthenia gravis (gMG). We conducted a parallel-group, multi-center prospective RCT using computer-generated block randomization. Adults with stabilized, gMG, and no contra-indication to exercise, were eligible. Participants received usual care alone or usual care and exercise. The exercise intervention consisted of 3-weekly 40 min sessions of an unsupervised, moderate-intensity home rowing program over 3 months. The primary endpoint was the change in HRQoL from randomization to post-intervention. Assessor-blinded secondary endpoints were exercise tolerance and effects on clinical, psychological and immunological status. Of 138 patients screened between October 2014 and July 2017, 45 were randomly assigned to exercise (n=23) or usual care (n=20). Although exercise was well tolerated, the intention-to-treat analysis revealed no evidence of improved HRQoL compared to usual care (MGQOL-15-F; mean adjusted between-groups difference of -0.8 points, 95%CI -5.4 to 3.7). Two patients hospitalized for MG exacerbation were from the usual care group. (C) 2021 Elsevier B.V. All rights reserved.

引用

页码：726 / 735

页数：10

共 38 条

[1] Responsiveness and Clinically Meaningful Improvement, According to Disability Level, of Five Walking Measures After Rehabilitation in Multiple Sclerosis: A European Multicenter Study [J].