Synthesis of 2-[3-Aryl-3-(5-phenylisoxazol-3-yl)propyl] Derivatives of 5,5-Dimethylcyclohexane- and Cyclopenthane-1,3-diones Proceeding from 2-(4-Nitro-3-arylbutyl) Precursors

被引：0
|
作者：
Dontsu, Yu. S. [1 ]
Pashkovskii, F. S. [1 ]
Rubinov, D. B. [1 ]
Lakhvich, F. A. [1 ]
机构：
[1] Belarus Acad Sci, Inst Bioorgan Chem, Ul Acad Kuprevicha 5-2, Minsk 220141, BELARUS
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 54卷 / 08期
关键词：
ISOXAZOLE; CYCLOADDITIONS; ANTICANCER; SCAFFOLD; DESIGN;
D O I：
10.1134/S1070428018080195
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Regiospecific reduction of carbonyl group of acyl chain in the previously described 4-nitro-3-arylbutanoyl derivatives of dimedone and cyclopentane-1,3-dione was performed. On the basis of nitromethyl group of the enol derivatives of the reduction products obtained from the mentioned compounds nitrile oxide intermediates were prepared, which in situ reacted with phenylacetylene to form the corresponding isoxazole derivatives.
引用
收藏
页码：1232 / 1240
页数：9
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