Synthesis of 2-[3-Aryl-3-(5-phenylisoxazol-3-yl)propyl] Derivatives of 5,5-Dimethylcyclohexane- and Cyclopenthane-1,3-diones Proceeding from 2-(4-Nitro-3-arylbutyl) Precursors

被引：0

作者：

Dontsu, Yu. S. ^{[1
]}

Pashkovskii, F. S. ^{[1
]}

Rubinov, D. B. ^{[1
]}

Lakhvich, F. A. ^{[1
]}

机构：

[1] Belarus Acad Sci, Inst Bioorgan Chem, Ul Acad Kuprevicha 5-2, Minsk 220141, BELARUS

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 54卷 / 08期

关键词：

ISOXAZOLE; CYCLOADDITIONS; ANTICANCER; SCAFFOLD; DESIGN;

D O I：

10.1134/S1070428018080195

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regiospecific reduction of carbonyl group of acyl chain in the previously described 4-nitro-3-arylbutanoyl derivatives of dimedone and cyclopentane-1,3-dione was performed. On the basis of nitromethyl group of the enol derivatives of the reduction products obtained from the mentioned compounds nitrile oxide intermediates were prepared, which in situ reacted with phenylacetylene to form the corresponding isoxazole derivatives.

引用

页码：1232 / 1240

页数：9

共 50 条

[21] Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles
Milinkevich, Kristin A.
Yoo, Choong L.
Sparks, Thomas C.
Lorsbach, Beth A.
Kurth, Mark J.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (19) : 5796 - 5798
[22] Synthesis of 2-(2,6-Dihalophenyl)-3-(4,5,6-trimethyl-pyrimidin-2-yl)4-oxothiazolidin-5-yl Carboxylates by Pummerer Reaction
Chen, Hua
Guo, Zaihong
Yin, Qingmei
Li, Xiaoliu
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 31 (02) : 249 - 255
[23] Synthesis, DFT computations, molecular docking studies and anticancer activity of 2-(4-fluorophenyl)-3-(5-methylisoxazol-3-yl)thiazolidin-4-one
Ramesh, Gaddam
Rathnakar, Bethi
Narsaiah, Chelimela
Rameshwar, Nimma
Srinivas, Marri
Namratha, Vaddiraju
Durgaiah, Gandamalla
Reddy, Yellu Narsimha
Reddy, Byru Venkatram
Satyanarayana, Mavurapu
CHEMICAL DATA COLLECTIONS, 2022, 39
[24] Synthesis, cytotoxic evaluation of novel 2-((1H-indol-3-yl) methyl)-5-alkyl-1,3,4-oxadiazole and 2-alkyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole derivatives
Vijayendar, Venepally
Routhu, Sunitha Rani
Kumar, C. Ganesh
Jala, Ram Chandra Reddy
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2020, 59 (04): : 465 - 473
[25] Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives
Liu, Xin-Hua
Zhu, Jing
Zhou, An-na
Song, Bao-An
Zhu, Hai-Liang
bai, Lin-Shan
Bhadury, Pinaki S.
Pan, Chun-Xiu
BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (03) : 1207 - 1213
[26] The 2-((5-(3-(2-Fluorophenyl)acryloyl)-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione
Fedusevych, Olha-Maria
Lozynskyi, Andrii
Sulyma, Marta
Lesyk, Roman
MOLBANK, 2024, 2024 (01)
[27] Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-,4,7-ethanoisoindole-1,3(2H)-dione derivatives
Ozbek, Oguz
Usta, Necibe Canan
Gurdere, Meliha Burcu
Aslan, Osman Nuri
Budak, Yakup
Ceylan, Mustafa
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2017, 192 (10) : 1153 - 1157
[28] Synthesis and pharmacological evaluation of some novel 2-(5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles
Aggarwal, Ranjana
Kumar, Sunil
Kaushik, Pawan
Kaushik, Dhirender
Gupta, Girish Kumar
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 62 : 508 - 514
[29] One-pot, two-step synthesis and photophysical properties of 2-(5-phenylindol-3-yl) benzimidazole derivatives
Lyu, Liu
Cai, Liu
Wang, Yun
Huang, Jinfeng
Zeng, Xiangchao
Liu, Porun
RSC ADVANCES, 2017, 7 (78) : 49374 - 49385
[30] Synthesis and Antimicrobial Activity of 3-{2-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]-5-fluorophenyl}isoxazoles
K. Santhosh Kumar
S. Mohanty
G. P. Reddy
V. Siddaiah
J. D. Lilakar
G. L. Goud
Russian Journal of General Chemistry, 2019, 89 : 1221 - 1224

← 1 2 3 4 5 →