Role of Non-Invasive Respiratory Supports in COVID-19 Acute Respiratory Failure Patients with Do Not Intubate Orders

被引：4

作者：

Medrinal, Clement ^{[1
,2
,3
]}

Gillet, Alexis ^{[4
]}

Boujibar, Fairuz ^{[5
,6
]}

Dugernier, Jonathan ^{[7
]}

Zwahlen, Marcel ^{[8
]}

Lamia, Bouchra ^{[9
,10
,11
]}

Girault, Christophe ^{[9
,12
]}

Creteur, Jacques ^{[13
]}

Fellrath, Jean-Marc ^{[14
]}

Haesler, Laurence ^{[9
,15
]}

Lagache, Laurie ^{[2
]}

Goubert, Laure ^{[10
]}

Macari, Elise Artaud ^{[9
,16
]}

Taton, Olivier ^{[17
]}

Gouin, Philippe ^{[12
]}

Leduc, Dimitri ^{[17
]}

Van Hove, Olivier ^{[4
,17
]}

Norrenberg, Michelle ^{[4
,13
]}

Prieur, Guillaume ^{[9
,10
,18
]}

Combret, Yann ^{[9
,10
]}

Correvon, Nils ^{[7
,19
]}

Hilfiker, Roger ^{[20
]}

Contal, Olivier ^{[19
]}

机构：

[1] Paris Saclay Univ, Erphan, UVSQ, F-78000 Versailles, France

[2] Le Havre Hosp, Intens Care Unit Dept, Ave Pierre Mendes France, F-76290 Montivilliers, France

[3] Paris Saclay Univ, St Michel Sch Physiotherapy, F-75015 Paris, France

[4] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Physiotherapy, B-1070 Brussels, Belgium

[5] Rouen Univ Hosp, Inserm U1096, F-76000 Rouen, France

[6] Rouen Univ Hosp, Dept Gen & Thorac Surg, F-76000 Rouen, France

[7] RHNe Reseau Hosp Neuchatelois, Pourtales Hosp, Physiotherapy Unit, CH-2000 Neuchatel, Switzerland

[8] Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland

[9] Normandie Univ, Inst Res & Innovat Biomed IRIB, UNIROUEN, EA3830 GRHV, F-76000 Rouen, France

[10] Le Havre Hosp, Pulmonol Dept, Ave Pierre Mendes France, F-76290 Montivilliers, France

[11] Rouen Univ Hosp, Resp Dept, Pulmonol, F-76000 Rouen, France

[12] Rouen Univ Hosp, Intens Care Unit Dept, F-76000 Rouen, France

[13] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, B-1070 Brussels, Belgium

[14] RHNe Reseau Hosp Neuchatelois, Pourtales Hosp, Pulm Med Unit, CH-2000 Neuchatel, Switzerland

[15] RHNe Reseau Hosp Neuchatelois, Pourtales Hosp, Intens Care Unit, CH-2000 Neuchatel, Switzerland

[16] Rouen Univ Hosp, Pulm Thorac Oncol & Resp Intens Care Dept, F-76000 Rouen, France

[17] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Pneumol, B-1070 Brussels, Belgium

[18] Louvain Catholic Univ, Res & Clin Expt Inst IREC, Pulmonol ORL & Dermatol, B-1200 Brussels, Belgium

[19] HES SO Univ Appl Sci & Arts Western Switzerland, Sch Hlth Sci HESAV, CH-1011 Lausanne, Switzerland

[20] Univ Appl Sci & Arts Western Switzerland Valais H, Sch Hlth Sci, CH-3954 Leukerbad, Switzerland

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 13期

关键词：

COVID-19; CPAP; high flow nasal cannula; mechanical ventilation; oxygenation; MORTALITY; OUTCOMES; SOFA;

D O I：

10.3390/jcm10132783

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The current gold-standard treatment for COVID-19-related hypoxemic respiratory failure is invasive mechanical ventilation. However, do not intubate orders (DNI), prevent the use of this treatment in some cases. The aim of this study was to evaluate if non-invasive ventilatory supports can provide a good therapeutic alternative to invasive ventilation in patients with severe COVID-19 infection and a DNI. Data were collected from four centres in three European countries. Patients with severe COVID-19 infection were included. We emulated a hypothetical target trial in which outcomes were compared in patients with a DNI order treated exclusively by non-invasive respiratory support with patients who could be intubated if necessary. We set up a propensity score and an inverse probability of treatment weighting to remove confounding by indication. Four-hundred patients were included: 270 were eligible for intubation and 130 had a DNI order. The adjusted risk ratio for death among patients eligible for intubation was 0.81 (95% CI 0.46 to 1.42). The median length of stay in acute care for survivors was similar between groups (18 (10-31) vs. (19 (13-23.5); p = 0.76). The use of non-invasive respiratory support is a good compromise for patients with severe COVID-19 and a do not intubate order.

引用

页数：11

共 34 条

[1] Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update [J].

Alhazzani, Waleed ;

Evans, Laura ;

Alshamsi, Fayez ;

Moller, Morten Hylander ;

Ostermann, Marlies ;

Prescott, Hallie C. ;

Arabi, Yaseen M. ;

Loeb, Mark ;

Gong, Michelle Ng ;

Fan, Eddy ;

Oczkowski, Simon ;

Levy, Mitchell M. ;

Derde, Lennie ;

Dzierba, Amy ;

Du, Bin ;

Machado, Flavia ;

Wunsch, Hannah ;

Crowther, Mark ;

Cecconi, Maurizio ;

Koh, Younsuck ;

Burry, Lisa ;

Chertow, Daniel S. ;

Szczeklik, Wojciech ;

Belley-Cote, Emilie ;

Greco, Massimiliano ;

Bala, Malgorzata ;

Zarychanski, Ryan ;

Kesecioglu, Jozef ;

McGeer, Allison ;

Mermel, Leonard ;

Mammen, Manoj J. ;

Myatra, Sheila Nainan ;

Arrington, Amy ;

Kleinpell, Ruth ;

Citerio, Giuseppe ;

Lewis, Kimberley ;

Bridges, Elizabeth ;

Memish, Ziad A. ;

Hammond, Naomi ;

Hayden, Frederick G. ;

Alshahrani, Muhammed ;

Al Duhailib, Zainab ;

Martin, Greg S. ;

Kaplan, Lewis J. ;

Coopersmith, Craig M. ;

Antonelli, Massimo ;

Rhodes, Andrew .

CRITICAL CARE MEDICINE, 2021, 49 (03) :E219-E234

[2] Helmet CPAP treatment in patients with COVID-19 pneumonia: a multicentre cohort study [J].

Aliberti, Stefano ;

Radovanovic, Dejan ;

Billi, Filippo ;

Sotgiu, Giovanni ;

Costanzo, Matteo ;

Pilocane, Tommaso ;

Saderi, Laura ;

Gramegna, Andrea ;

Rovellini, Angelo ;

Perotto, Luca ;

Monzani, Valter ;

Santus, Pierachille ;

Blasi, Francesco .

EUROPEAN RESPIRATORY JOURNAL, 2020, 56 (04)

[3] Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study [J].

Alviset, Sophie ;

Riller, Quentin ;

Aboab, Jerome ;

Dilworth, Kelly ;

Billy, Pierre-Antoine ;

Lombardi, Yannis ;

Azzi, Mathilde ;

Ferreira Vargas, Luis ;

Laine, Laurent ;

Lermuzeaux, Mathilde ;

Memain, Nathalie ;

Silva, Daniel ;

Tchoubou, Tona ;

Ushmorova, Daria ;

Dabbagh, Hanane ;

Escoda, Simon ;

Lefrancois, Remi ;

Nardi, Annelyse ;

Ngima, Armand ;

Ioos, Vincent .

PLOS ONE, 2020, 15 (10)

[4] Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure [J].

Arina, Pietro ;

Baso, Beatrice ;

Moro, Valeria ;

Patel, Hemani ;

Ambler, Gareth .

INTENSIVE CARE MEDICINE, 2021, 47 (02) :237-239

[5] Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID) [J].

Bellani, Giacomo ;

Grasselli, Giacomo ;

Cecconi, Maurizio ;

Antolini, Laura ;

Borelli, Massimo ;

De Giacomi, Federica ;

Bosio, Giancarlo ;

Latronico, Nicola ;

Filippini, Matteo ;

Gemma, Marco ;

Giannotti, Claudia ;

Antonini, Benvenuto ;

Petrucci, Nicola ;

Zerbi, Simone Maria ;

Maniglia, Paolo ;

Castelli, Gian Paolo ;

Marino, Giovanni ;

Subert, Matteo ;

Citerio, Giuseppe ;

Radrizzani, Danilo ;

Mediani, Teresa S. ;

Lorini, Ferdinando Luca ;

Russo, Filippo Maria ;

Faletti, Angela ;

Beindorf, Andrea ;

Covello, Remo Daniel ;

Greco, Stefano ;

Bizzarri, Marta M. ;

Ristagno, Giuseppe ;

Mojoli, Francesco ;

Pradella, Andrea ;

Severgnini, Paolo ;

Da Macalle, Marta ;

Albertin, Andrea ;

Ranieri, V. Marco ;

Rezoagli, Emanuele ;

Vitale, Giovanni ;

Magliocca, Aurora ;

Cappelleri, Gianluca ;

Docci, Mattia ;

Aliberti, Stefano ;

Serra, Filippo ;

Rossi, Emanuela ;

Valsecchi, Maria Grazia ;

Pesenti, Antonio ;

Foti, Giuseppe .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2021, 18 (06) :1020-1026

[6] Failure of Noninvasive Ventilation for De Novo Acute Hypoxemic Respiratory Failure: Role of Tidal Volume [J].

Carteaux, Guillaume ;

Millan-Guilarte, Teresa ;

De Prost, Nicolas ;

Razazi, Keyvan ;

Abid, Shariq ;

Thille, Arnaud W. ;

Schortgen, Frederique ;

Brochard, Laurent ;

Brun-Buisson, Christian ;

Dessap, Armand Mekontso .

CRITICAL CARE MEDICINE, 2016, 44 (02) :282-290

[7] Constructing inverse probability weights for marginal structural models [J].

Cole, Stephen R. ;

Hernan, Miguel A. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 168 (06) :656-664

[8] Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome [J].

Combes, A. ;

Hajage, D. ;

Capellier, G. ;

Demoule, A. ;

Lavoue, S. ;

Guervilly, C. ;

Da Silva, D. ;

Zafrani, L. ;

Tirot, P. ;

Veber, B. ;

Maury, E. ;

Levy, B. ;

Cohen, Y. ;

Richard, C. ;

Kalfon, P. ;

Bouadma, L. ;

Mehdaoui, H. ;

Beduneau, G. ;

Lebreton, G. ;

Brochard, L. ;

Ferguson, N. D. ;

Fan, E. ;

Slutsky, A. S. ;

Brodie, D. ;

Mercat, A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (21) :1965-1975

[9] Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak [J].

Coppadoro, Andrea ;

Benini, Annalisa ;

Fruscio, Robert ;

Verga, Luisa ;

Mazzola, Paolo ;

Bellelli, Giuseppe ;

Carbone, Marco ;

Mulinacci, Giacomo ;

Soria, Alessandro ;

Noe, Beatrice ;

Beck, Eduardo ;

Di Sciacca, Riccardo ;

Ippolito, Davide ;

Citerio, Giuseppe ;

Valsecchi, Maria Grazia ;

Biondi, Andrea ;

Pesci, Alberto ;

Bonfanti, Paolo ;

Gaudesi, Davide ;

Bellani, Giacomo ;

Foti, Giuseppe .

CRITICAL CARE, 2021, 25 (01)

[10] Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study [J].

Cummings, Matthew J. ;

Baldwin, Matthew R. ;

Abrams, Darryl ;

Jacobson, Samuel D. ;

Meyer, Benjamin J. ;

Balough, Elizabeth M. ;

Aaron, Justin G. ;

Claassen, Jan ;

Rabbani, LeRoy E. ;

Hastie, Jonathan ;

Hochman, Beth R. ;

Salazar-Schicchi, John ;

Yip, Natalie H. ;

Brodie, Daniel ;

O'Donnell, Max R. .

LANCET, 2020, 395 (10239) :1763-1770

← 1 2 3 4 →